64399-26-4

Usage

Uses

Used in Pharmaceutical Industry:
1-(4-Chlorophenyl)-1-cyclopentanecarbonitrile is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique chemical structure allows for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, 1-(4-Chlorophenyl)-1-cyclopentanecarbonitrile is utilized as a precursor for the production of various agrochemicals, such as insecticides and herbicides. Its chemical properties make it suitable for the development of effective and targeted pest control solutions.
Used in Organic Synthesis:
1-(4-Chlorophenyl)-1-cyclopentanecarbonitrile serves as an important intermediate in the synthesis of a wide range of organic compounds. Its versatile chemical properties enable the creation of new molecules with diverse applications in various industries.
Safety Precautions:
It is crucial to handle 1-(4-Chlorophenyl)-1-cyclopentanecarbonitrile with caution, as it may be harmful if ingested or comes in contact with the skin or eyes. Proper safety measures, such as wearing protective gear and following handling guidelines, should be strictly adhered to during its use in any application.

InChI:InChI=1/C12H12ClN/c13-11-5-3-10(4-6-11)12(9-14)7-1-2-8-12/h3-6H,1-2,7-8H2

Upstream product

• 110-56-5 1,4-dichlorobutane 
• 140-53-4 p-chlorobenzyl cyanide 
• 110-52-1 1,4-dibromo-butane 
• 4254-02-8 cyclopentanecarbonitrile 
• 106-39-8 bromochlorobenzene 

Downstream Products

• 80789-69-1 1-(4-chlorophenyl)cyclopentane-1-carboxylic acid 
• 1616922-78-1 [1-(4-chlorophenyl)cyclopentyl]acetonitrile 
• 1616922-77-0 methanesulfonic acid 1-(4-chlorophenyl)cyclopentylmethyl ester 
• 189810-98-8 1-(4-chlorophenyl)cyclopentane-1-carbaldehyde 
• 143407-77-6 Sodium; (6R,7R)-3-acetoxymethyl-7-{[1-(4-chloro-phenyl)-cyclopentanecarbonyl]-amino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate 
• 143407-73-2 Sodium; (6R,7R)-7-{[1-(4-chloro-phenyl)-cyclopentanecarbonyl]-amino}-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate 
• 143407-69-6 Sodium; (2S,5R,6R)-6-{[1-(4-chloro-phenyl)-cyclopentanecarbonyl]-amino}-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate 
• 71501-44-5 1-(4-chlorophenyl)cyclopentane-1-carboxylic acid chloride 
• 162780-92-9 <1-(p-Chlorophenyl)cyclopentyl>carbinyl tosylate 
• 80866-79-1 <1-(p-Chlorophenyl)cyclopentyl>carbinol 

Relevant academic research and scientific papers

Synthesis and Biological Activity of Arylcyclopentane-1-carboxylic Acids Aminoesters

1-Arylcyclopentane-1-carboxylic acids were synthesized by alkaline hydrolysis of the corresponding nitriles. Reactions of the acid chlorides with N,N-dialkylaminoalkyl-and hetarylalkylalkanols provided new aminoester derivatives of 1-arylcyclopentane-1-carboxylic acids. Sympatholytic and adrenolytic activity of the obtained amino esters hydrochlorides was studied.

CHEMOSELECTIVE METHYLENE HYDROXYLATION IN AROMATIC MOLECULES

A chemoselective and reactive Mn(CF3-PDP) catalyst system that enables for the first time the strategic advantages of late-stage aliphatic C—H hydroxylation to be leveraged in aromatic compounds. This discovery will benefit small molecule therapeutics by enabling the rapid diversification of aromatic drugs and natural products and identification of their metabolites.

PYRIMIDONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE

The present invention relates to a compound having the general formula (I), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which are useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.

Development of a palladium-catalyzed α-arylation of cyclopropyl nitriles

1,1-Disubstituted aryl cyclopropyl nitriles are useful moieties in biologically active compounds and provide access to a range of cyclopropyl derivatives. Herein, we describe the development of a palladium-catalyzed α-arylation of cyclopropyl, cyclobutyl, and cyclopentyl nitriles that affords these functional groups in one step from a variety of aryl bromides in good to excellent yields. Furthermore, we demonstrate the transformation of aryl cyclopropyl nitriles into aryl trifluoromethyl cyclopropanes.