644-42-8

Basic information

• Product Name: 2-(3-methylimidazol-4-yl)ethanamine
• Synonyms: 2-(3-methylimidazol-4-yl)ethanamine;3-Methylhistamine;1-Methyl-1H-imidazole-5-ethanamine;1-Methyl-5-(2-aminoethyl)-1H-imidazole
• CAS NO: 644-42-8
• Molecular Formula: C₆H₁₁N₃
• Molecular Weight: 125.17
• Mol File: 644-42-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 296.7°C at 760 mmHg
• Flash Point: 133.2°C
• Appearance: /
• Density: 1.11g/cm³
• Vapor Pressure: 0.00141mmHg at 25°C
• Refractive Index: 1.564
• PKA: pK1:5.80(＋1);pK2:9.90(0) (25°C)
• CAS DataBase Reference: 2-(3-methylimidazol-4-yl)ethanamine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-methylimidazol-4-yl)ethanamine(644-42-8)
• EPA Substance Registry System: 2-(3-methylimidazol-4-yl)ethanamine(644-42-8)

Safety Data

• Hazardous Substances Data: 644-42-8(Hazardous Substances Data)

Usage

Chemical class

Amines

Functional group

3-methylimidazol-4-yl group

Structure

Ethanamine structure

Common uses

Building block in the synthesis of pharmaceuticals and organic compounds

Potential applications

Medicinal chemistry and drug development

Properties

Ability to interact with biological targets and exhibit pharmacological properties

Additional research

Necessary to fully understand its potential uses and effects

InChI:InChI=1/C6H11N3/c1-9-5-8-4-6(9)2-3-7/h4-5H,2-3,7H2,1H3

Upstream product

• 18502-05-1 4-cyanomethylimidazole 
• 673-49-4 N-acetylhistamine 
• 77-78-1 dimethyl sulfate 
• 41065-01-4 1-Methyl-5-cyanomethyl-imidazol 

Downstream Products

• 154965-36-3 3-[[(2R,3S,5R)-3-Hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxy]-bis-(4-methoxy-phenyl)-methyl]-N-[2-(3-methyl-3H-imidazol-4-yl)-ethyl]-benzamide 
• 154985-88-3 Dithiophosphoric acid O-[(2R,3S,5R)-2-(bis-(4-methoxy-phenyl)-{3-[2-(3-methyl-3H-imidazol-4-yl)-ethylcarbamoyl]-phenyl}-methoxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester 

Relevant articles and documents

The selective synthesis of 1-methyl-1H-histamines

The selective synthesis of 1-methyl-1H-4-histamine (1) and 1-methyl-1H-5-histamine (2) via 5-oxo-5,6,7,8-tetrahydroimidazo[1,5-c]pyrimidine (3) from commercially available histamine hydrochloride salt is described.