64409-12-7

Usage

Uses

Used in Electronics Industry:
4-(4-Mercaptophenyl)benzonitrile is used as a self-assembled monolayer (SAM) for gold surfaces to tune their electronic properties and control surface coverage. The thiol group forms a strong covalent bond with the gold surface, while the nitrile group can interact with other molecules or materials, enabling the creation of functionalized surfaces for various electronic applications.
Used in Surface Modification:
In the field of surface modification, 4-(4-Mercaptophenyl)benzonitrile is used as a surface modifier to alter the properties of gold surfaces. 4-(4-mercaptophenyl)benzonitrile can be used to create a stable and well-ordered monolayer on gold surfaces, which can then be further functionalized with other molecules or materials to achieve desired surface properties, such as improved biocompatibility, enhanced catalytic activity, or increased stability.
Used in Sensors and Biosensors:
4-(4-Mercaptophenyl)benzonitrile can be employed in the development of sensors and biosensors due to its ability to form stable monolayers on gold surfaces and its potential for further functionalization. 4-(4-mercaptophenyl)benzonitrile can be used to create selective binding sites for target molecules, enabling the detection of specific analytes in complex samples.
Used in Catalysis:
In the field of catalysis, 4-(4-Mercaptophenyl)benzonitrile can be used to modify gold surfaces, enhancing their catalytic properties. 4-(4-mercaptophenyl)benzonitrile can be used to create active sites on gold surfaces for various chemical reactions, such as oxidation, reduction, or hydrolysis, by functionalizing the surface with specific ligands or catalysts.

Upstream product

• 130782-76-2 4-cyano-4'-[[dimethylaminocarbonyl]sulfanyl]-1,1-biphenyl 
• 19812-93-2 4-Cyano-4'-hydroxybiphenyl 
• 130782-66-0 4-Cyano-4'-[[(dimethylamino)carbothioyl]oxy]-1,1'-biphenyl 
• 960494-10-4 C₂₂H₂₉NSSi 
• 57774-34-2 4′-iodo-[1,1′-biphenyl]-4-carbonitrile 

Downstream Products

• 149503-71-9 (3S,5S)-5-[(4'-Cyano-4-biphenylyl)sulphenylmethyl]-3-[(methoxycarbonyl)methyl]-1-(3-phenylpropyl)-2-pyrrolidinone 
• 396131-77-4 N-[1-(4'-cyanobiphenyl-4-sulfanylmethyl)-2-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)ethyl]-N-hydroxyformamide 
• 396131-72-9 4'-[3-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-oxopropylsufanyl]biphenyl-4-carbonitrile 

Relevant academic research and scientific papers

Direct probing molecular twist and tilt in aromatic self-assembled monolayers

Using a nitrile tailgroup as a spectroscopic marker, both twist and tilt of the aromatic backbones in several typical aromatic SAMs on Au(111) have been directly determined in a single experiment. Whereas the exact value of the twist angle depends on the molecular architecture, it was found to be quite noticeable in all SAMs (40-50°) and close to the respective value for aromatic bulk systems (32°). Copyright

3-Arylsulfonyl-2 (substituted methyl) propanoic acid derivatives as matrix metalloproteinase inhibitors

Compounds which are 3-arylsulfonyl-2-methyl propanoic acid derivatives of formula (I): wherein X is HO—NH— or HO—, R1 is selected from phenyl, 4-chlorophenyl, 4-florophenyl, 4-cyanophenyl, benzamido (i.e., —NH—CO-Ph) and benzamido substituted on the terminal phenyl ring by C1-C4alkyl, fluoro, chloro, cyano or C1-4alkoxy; R2is selected from (a) —S—Ar or —S—CH2—Ar wherein Ar is an aromatic moiety; (b) —O—Ar wherein Ar is as defined above; (c) —S-Het or —S—CH2-Het wherein Het is a heterocyclic ring; and (d) 2,5-dioxo-1-imidazolidinyl or 2,4-dioxo-1-imidazolinyl; and the pharmaceutically acceptable salts thereof; have potent and selective inhibitory activity against matrix metalloproteinases (MMPs) and can thus be used in the treatment and prevention of diseases mediated by MMPs.

Phenoxyphenyl sulfone N-formylhydroxylamines (Retrohydroxamates) as potent, selective, orally bioavailable matrix metalloproteinase inhibitors

A novel series of sulfone N-formylhydroxylamines (retrohydroxamates) have been investigated as matrix metalloproteinases (MMP) inhibitors. The substitution of the ether linkage of ABT-770 (5) with a sulfone group 13a led to a substantial increase in activity against MMP-9 but was accompanied by a loss of selectivity for inhibition of MMP-2 and -9 over MMP-1 and diminished oral exposure. Replacement of the biphenyl P1′ substituent with a phenoxyphenyl group provided compounds that are highly selective for inhibition of MMP-2 and -9 over MMP-1. Optimization of the substituent adjacent to the retrohydroxamate center in this series led to the clinical candidate ABT-518 (6), a.highly potent, selective, orally bioavailable MMP inhibitor that has been shown to significantly inhibit tumor growth in animal cancer models.

Cyclic imino derivatives and pharmaceutical compositions containing them

The invention relates to cyclic imino compounds which have, inter alia, valuable pharmacological properties, especially inhibitory effects on cell aggregation, pharmaceutical compositions which contain these compounds and processes for preparing them.

β-D-phenylthioxylosides, their method of preparation and their use as therapeutic agents

The present invention relates, by way of novel industrial products, to the β-D-phenylthioxyloside compounds of the formula STR1 in which: X represents a sulfur atom or an oxygen atom; R1, R2 and R3, which are identical or different, each represent a hydrogen atom, a nitro group, a cyano group, a group --CO--R (in which R represents a C1 -C4 alkyl group or a trifluoromethyl group), an amino group, an acetamido group (NHCOCH3), a C1 -C4 alkoxy group, a trifluoromethyl group or a phenyl group substituted by one or more cyano, nitro or trifluoromethyl groups, it being possible for R1 and R2, taken together, to form, with the phenyl group to which they are bonded, a β-naphthalenyl group which is unsubstituted or substituted by one or more cyano, nitro or trifluoromethyl groups; and Y represents the hydrogen atom or an aliphatic acyl group. These compounds are useful as therapeutic agents, especially as venous antithrombotics.