64414-74-0

Basic information

• Product Name: N4-(4-chloro-phenyl)-pyrimidine-2,4,6-triamine
• Synonyms: N4-(4-chloro-phenyl)-pyrimidine-2,4,6-triamine
• CAS NO: 64414-74-0
• Molecular Formula: C₁₀H₁₀ClN₅
• Molecular Weight: 236
• Mol File: 64414-74-0.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N4-(4-chloro-phenyl)-pyrimidine-2,4,6-triamine(CAS DataBase Reference)
• NIST Chemistry Reference: N4-(4-chloro-phenyl)-pyrimidine-2,4,6-triamine(64414-74-0)
• EPA Substance Registry System: N4-(4-chloro-phenyl)-pyrimidine-2,4,6-triamine(64414-74-0)

Safety Data

• Hazardous Substances Data: 64414-74-0(Hazardous Substances Data)

Upstream product

• 156-83-2 6-chloro-pyrimidine-2,4-diyldiamine 
• 106-47-8 4-chloro-aniline 

Relevant articles and documents

Discovery of novel dual inhibitors of receptor tyrosine kinases EGFR and PDGFR-β related to anticancer drug resistance

With ongoing resistance problems against the marketed EGFR inhibitors having a quinazoline core scaffold there is a need for the development of novel inhibitors having a modified scaffold and, thus, expected lower EGFR resistance problems. An additional problem concerning EGFR inhibitor resistance is an observed heterodimerization of EGFR with PDGFR-β that neutralises the sole inhibitor activity towards EGFR. We developed novel pyrimido[4,5-b]indoles with varied substitution patterns at the 4-anilino residue to evaluate their EGFR and PDGFR-β inhibiting properties. We identified dual inhibitors of both EGFR and PDGFR-β in the nanomolar range which have been initially screened in cancer cell lines to prove a benefit of both EGFR and PDGFR-β inhibition.