64431-79-4

Upstream product

• 23464-45-1 6-(4-methoxyphenyl)-hexyl bromide 
• 22809-37-6 6-bromohexanoyl chloride 
• 123-08-0 4-hydroxy-benzaldehyde 
• 17814-85-6 (4-carboxybutyl)triphenylphosphonium bromide 
• 57840-61-6 6-bromo-1-(4-methoxyphenyl)-1-hexanone 
• 849675-06-5 6-(4-hydroxyphenyl)-1-hexanol 

Downstream Products

• 1027584-55-9 3-Cyano-3-hydroxy-4-[6-(4-hydroxy-phenyl)-hexylsulfanyl]-butyric acid methyl ester 
• 107228-95-5 7-(4-hydroxyphenyl)heptanoic acid 
• 52122-46-0 4-[6-(4-hydroxy-phenyl)-hexyl]-heptane-3,5-dione 
• 1027281-55-5 Thioacetic acid S-[6-(4-hydroxy-phenyl)-hexyl] ester 

Relevant academic research and scientific papers

Synthesis of 5-(ω-sulfhydrylalkyl)salicylaldehydes as precursors for the preparation of alkanethiol-modified metal salens

Using multistep syntheses, we obtained two alkanethiol-modified salicylaldehydes, namely 5-(2-sulfhydrylethyl)salicylaldehyde and 5-(6-sulfhydrylhexyl)salicylaldehyde. These compounds are precursors for the preparation of alkanethiol-substituted metal sal

ATP-citrate lyase as a target for hypolipidemic intervention. Design and synthesis of 2-substituted butanedioic acids as novel, potent inhibitors of the enzyme

ATP-citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Inhibitors of the enzyme represent a potentially novel class of hypolipidemic agent, which are anticipated to have combined hypocholesterolemic and hypotriglyceridemic properties. A series of 2-substituted butanedioic acids have been designed and synthesized as inhibitors of the enzyme. The best compounds, 58, 68, 71, 74 have reversible K(i)'s in the 1-3 μM range against the isolated rat enzyme. As representative of this compound class, 58, has been shown to exert its inhibitory action through a mainly competitive mechanism with respect to citrate and a noncompetitive one with respect to CoA. None of the inhibitors were able to inhibit cholesterol and/or fatty acid synthesis in HepG2 cells. This has been attributed to the adverse physicochemical properties of the molecules leading to a lack of cell penetration. Despite this, a lead structural class of compound has been identified with the potential for modification into potent, cell-penetrant, and efficacious inhibitors of ATP- citrate lyase.