64436-62-0

Usage

Uses

Used in Pharmaceutical Industry:
9-(pyridin-2-yl)-9H-fluoren-9-ol is used as a building block for the synthesis of various organic compounds and pharmaceuticals due to its versatile chemical structure and biological activities.
Used in Medicinal Chemistry Research:
9-(pyridin-2-yl)-9H-fluoren-9-ol is used as a valuable tool for researchers in the field of medicinal chemistry and drug discovery, given its potential in the development of new drugs with anti-inflammatory, anticancer, and antibacterial properties.
Used in Drug Development:
9-(pyridin-2-yl)-9H-fluoren-9-ol is employed in the development of new drugs, leveraging its diverse biological activities to target various medical conditions and improve therapeutic outcomes.

Upstream product

• 17624-36-1 2-pyridyllithium 
• 486-25-9 9-fluorenone 
• 2603-16-9 2-(9H-fluoren-9-yl)pyridine 
• 109-04-6 2-bromo-pyridine 

Downstream Products

• 86-73-7 9H-fluorene 
• 486-25-9 9-fluorenone 

Relevant academic research and scientific papers

Green synthesis method of polyaryl substituted methanol

The invention relates to a green synthesis method of polyaryl substituted methanol, in particular to a method for efficiently synthesizing polyaryl substituted methanol in a polar aprotic solvent under the condition of an oxidizing agent by taking polyaryl substituted methane as a raw material and alkali as an additive. The method provided by the invention is green and environment-friendly, avoids using expensive metal catalysts, and has the advantages of low cost, few reaction steps, short time, high yield and the like.

Transition-Metal Free Chemoselective Hydroxylation and Hydroxylation-Deuteration of Heterobenzylic Methylenes

We developed an approach for direct selective hydroxylation of heterobenzylic methylenes to secondary alcohols avoiding overoxidation to ketones by using a KOBu-t/DMSO/air system. Most reactions could reach completion in several minutes to give hydroxylated products in 41-76% yields. Using DMSO-d6, this protocol resulted in difunctionalization of heterobenzylic methylenes to afford α-deuterated secondary alcohols (>93% incorporation). By employing this method, active pharmaceutical ingredients carbinoxamine and doxylamine were synthesized in two steps in moderate yields.

Organic compound containing fluorene and pyridino-indole and application thereof

The invention relates to an organic compound containing fluorene and pyridino-indole and an application thereof in organic light emission diodes devices. The compound utilized a benzo five-membered ring as a core and is connected with a pyridyl group or a pyridino-indole group. The compound of the invention has high glass transition temperature and high bond dissociation energy, so that the service life of the OLED devices can be improved; the compound also has a deep HOMO energy level and high electron mobility, and can be used as hole blocking layer/electron transfer layer materials of the OLED devices or a material of a partial electron type main body, holes or energy can be effectively blocked from being transmitted from a light emitting layer to one side of an electron layer, therebyimproving the recombination efficiency of holes and electrons in the light emitting layer, and the luminous efficiency of the OLED devices is improved.

Use of Charge-Charge Repulsion to Enhance π-Electron Delocalization into Anti-Aromatic and Aromatic Systems

A series of 9-fluorenyl cations has been studied and it is shown that increasing charge on a heterocyclic substituent group enhances the anti-aromatic character of the carbocation system. Similarly, a series of dibenzosuberenyl cations has been studied and increasing charge on a substituent group is shown to enhance aromatic character in the carbocation system. These studies include the direct observations of dicationic and tricationic species using stable-ion conditions and low temperature NMR. The structures of these ions were further characterized using DFT calculations, confirming that highly charged organic ions may exhibit unusual distributions of π-electrons and delocalization of electrons in 4n or 4n+2 π-systems.

Indolopyridines with a bridging heteroatom. 9. Synthesis, structure, and thermolysis of 5-hydroxy-5-(2-pyridyl)-fluorene and -4-azafluorene

Treatment of fluorenone or 4-azafluoren-9-one with 2-pyridyllithium gives 5-hydroxy-5-(2-pyridyl)fluorene and its aza analog. The structure of the former has been studied by x-ray crystallography. It was found that, in contrast to the non-condensed diaryl-2-pyridylcarbinols, these alcohols do not undergo acid catalyzed dehydration and heterocyclization. Under pyrolytic conditions, 5-pyridylfluorenol undergoes fission to form fluorenone. 1997 Plenum Publishing Corporation.