64440-74-0

Usage

Uses

Used in Pharmaceutical Research:
Pyrazinecarbonitrile, 3-amino-6-formyl(9CI) is used as a building block in pharmaceutical research for the synthesis of various derivatives and analogs. Its unique structure and functional groups contribute to the development of new compounds with potential therapeutic applications.
Used in Organic Synthesis:
In the field of organic synthesis, Pyrazinecarbonitrile, 3-amino-6-formyl(9CI) is employed as a versatile intermediate for the creation of a wide range of chemical compounds. Its reactivity and functional groups enable the formation of diverse molecular structures, expanding the scope of synthetic chemistry.
Used in Anti-inflammatory Applications:
Pyrazinecarbonitrile, 3-amino-6-formyl(9CI) has been studied for its potential anti-inflammatory properties. It may be used as a therapeutic agent or a precursor in the development of new anti-inflammatory drugs, offering a promising avenue for the treatment of various inflammatory conditions.
Used in Anti-cancer Applications:
Pyrazinecarbonitrile, 3-amino-6-formyl(9CI) has also been investigated for its anti-cancer activities. Pyrazinecarbonitrile, 3-amino-6-formyl(9CI) may be utilized as a chemotherapeutic agent or a component in the design of novel anti-cancer drugs, targeting specific cancer cells and inhibiting their growth and proliferation.
Used in Industrial Chemistry:
In industrial chemistry, Pyrazinecarbonitrile, 3-amino-6-formyl(9CI) finds applications in the synthesis of various chemical products, such as dyes, pigments, and other specialty chemicals. Its unique structure and reactivity make it a valuable component in the development of innovative industrial products.

Upstream product

• 40127-91-1 2-Amino-5-chloromethylpyrazine-3-carbonitrile 
• 40127-89-7 3-amino-6-(chloromethyl)-2-pyrazinecarbonitrile 4-oxide 
• 64440-76-2 3-amino-6-{[(4-dimethylamino-phenyl)-oxy-imino]-methyl}-pyrazine-2-carbonitrile 
• 64440-76-2 N-[p-(dimethylamino)phenyl]-α-(2-amino-3-cyano-5-pyrazinyl)nitrone 
• 64440-75-1 1-[(2-amino-3-cyano-5-pyrazinyl)methyl]pyridinium chloride 

Relevant academic research and scientific papers

Pterin–sulfa conjugates as dihydropteroate synthase inhibitors and antibacterial agents

The sulfonamide class of antibiotics has been in continuous use for over 70?years. They are thought to act by directly inhibiting dihydropteroate synthase (DHPS), and also acting as prodrugs that sequester pterin pools by forming dead end pterin–sulfonamide conjugates. In this study, eight pterin–sulfonamide conjugates were synthesized using a novel synthetic strategy and their biochemical and microbiological properties were investigated. The conjugates were shown to competitively inhibit DHPS, and inhibition was enhanced by the presence of pyrophosphate that is crucial to catalysis and is known to promote an ordering of the DHPS active site. The co-crystal structure of Yersinia pestis DHPS bound to one of the more potent conjugates revealed a mode of binding that is similar to that of the enzymatic product analog pteroic acid. The antimicrobial activities of the pterin–sulfonamide conjugates were measured against Escherichia coli in the presence and absence of folate precursors and dependent metabolites. These results show that the conjugates have appreciable antibacterial activity and act by an on target, anti-folate pathway mechanism rather than as simple dead end products.

Syntheses of labeled vitamers of folic acid to be used as internal standards in stable isotope dilution assays

[2H4]Folic acid was synthesized by deuterating p-aminobenzoic acid, which was then coupled to glutamic acid and 6-formylpterin, Using [2H4]folic acid as starting component enabled the preparation of labeled vitamers tetrahydrofolate, 5-formyltetrahydrofolate, 5-methyltetrahydrofolate, and 10-formylfolate which were characterized by electrospray mass spectrometry and collision-induced dissociation. The mass spectrometric studies confirmed that the compounds could be used as internal standards in stable isotope dilution assays.