644469-19-2Relevant academic research and scientific papers
Synthesis of a new ent-cyclozonarone angular analog, and comparison of its cytotoxicity and apoptotic effects with ent-cyclozonarone
Sobarzo, Natalia Quinones,Venegas, Ivan Montenegro,Sanchez, Cristian Salas,Catalan, Luis Espinoza,Rojas, Cristobal Carrasco,Valdivia, Valentina Ulloa,Garcia, Joan Villena,Fritis, Mauricio Cuellar
, p. 5517 - 5530 (2013)
The synthesis of a newangular analog 11 of cyclozonarone was achieved via Diels-Alder reaction between a sesquiterpene-1,3-diene and 1,4-benzoquinone. The cytotoxic activity of ent-cyclozonarone [(+)-10] and the angular (-)-cyclozonarone analog 11 has been determined in three human cancer cell lines and in normal fibroblasts using the sulforhodamine B assay. The analyzed isomers induce cell death in different cancer cell lines by eliciting nuclear condensation and fragmentation, decreasing mitochondrial membrane permeability and increasing caspase-3 activity, all traits indicating apoptosis, with the effects of (+)-10 being stronger than those of 11 in all cases.
