64460-85-1

Basic information

• Product Name: (2-AMINO-PHENYL)-ACETIC ACID ETHYL ESTER
• Synonyms: ETHYL 2-AMINOPHENYLACETATE;(2-AMINO-PHENYL)-ACETIC ACID ETHYL ESTER;Benzeneacetic acid, 2-aMino-, ethyl ester;ethyl 2-(2-aMinophenyl)acetate;Ethyl 2-aMinophenylaceta;Ethyl 2-aminobenzeneacetate;Ethyl o-aminophenylacetate;2-Amino-benzeneacetic acid ethyl ester
• CAS NO: 64460-85-1
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.22
• Product Categories: pharmacetical
• Mol File: 64460-85-1.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 292.8°C at 760 mmHg
• Flash Point: 149.7°C
• Appearance: /
• Density: 1.112
• Vapor Pressure: 0.0018mmHg at 25°C
• Refractive Index: 1.547
• PKA: 3.71±0.10(Predicted)
• CAS DataBase Reference: (2-AMINO-PHENYL)-ACETIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (2-AMINO-PHENYL)-ACETIC ACID ETHYL ESTER(64460-85-1)
• EPA Substance Registry System: (2-AMINO-PHENYL)-ACETIC ACID ETHYL ESTER(64460-85-1)

Safety Data

• Hazardous Substances Data: 64460-85-1(Hazardous Substances Data)

Usage

Description

(2-AMINO-PHENYL)-ACETIC ACID ETHYL ESTER, also known as ethyl 2-(2-aminophenyl)acetate or 1-(2-Aminophenyl)ethyl acetate, is an organic compound with the molecular formula C10H13NO2. It is a white solid at room temperature and is a derivative of phenylacetic acid. (2-AMINO-PHENYL)-ACETIC ACID ETHYL ESTER contains both an amine and an ester functional group, which makes it versatile for various chemical reactions and applications in research and industry.

Uses

Used in Pharmaceutical Industry:
(2-AMINO-PHENYL)-ACETIC ACID ETHYL ESTER is used as an intermediate or raw material for the synthesis of various drugs and pharmaceutical products. Its presence of both amine and ester functional groups allows for a wide range of chemical reactions, making it a valuable component in the development of new medications.
Used in Research and Development:
In the field of research and development, (2-AMINO-PHENYL)-ACETIC ACID ETHYL ESTER is utilized for its chemical properties and reactivity. Its ability to participate in various chemical reactions makes it a useful compound for exploring new chemical pathways and syntheses, potentially leading to the discovery of novel pharmaceuticals or other applications.

InChI:InChI=1/C10H13NO2/c1-2-13-10(12)7-8-5-3-4-6-9(8)11/h3-6H,2,7,11H2,1H3

Upstream product

• 59-48-3 2-oxoindole 
• 64-17-5 ethanol 
• 3740-52-1 2-(2-nitrophenyl)acetic acid 
• 31912-02-4 ethyl 2-nitrophenylacetate 

Downstream Products

• 1352126-70-5 2-[2-(benzoylamino)benzoylamino]phenylacetic acid 
• 1352126-69-2 C₂₄H₂₂N₂O₄ 
• 1352126-67-0 C₁₇H₁₆N₂O₅ 
• 1020727-37-0 [2-(7-chloro-quinolin-4-ylamino)-phenyl]-acetic acid ethyl ester 
• 83397-36-8 N-(2-ethoxycarbonylmethylphenyl)-L-glutamine 
• 629655-10-3 ethyl [2-(1H-tetraazol-1-yl)phenyl]acetate 
• 929519-98-2 C₂₁H₂₂Cl₂N₂O₅S 
• 186135-56-8 4-Ethoxy-2H,5H-1-benzazepin-2-one 

Relevant articles and documents

Structural optimization and in vitro profiling of N-phenylbenzamide-based farnesoid X receptor antagonists

Activation of the nuclear farnesoid X receptor (FXR) which acts as cellular bile acid sensor has been validated as therapeutic strategy to counter liver disorders such as non-alcoholic steatohepatitis by the clinical efficacy of obeticholic acid. FXR antagonism, in contrast, is less well studied and potent small molecule FXR antagonists are rare. Here we report the systematic optimization of a novel class of FXR antagonists towards low nanomolar potency. The most optimized compound antagonizes baseline and agonist induced FXR activity in a full length FXR reporter gene assay and represses intrinsic expression of FXR regulated genes in hepatoma cells. With this activity and a favorable toxicity-, stability- and selectivity-profile it appears suitable to further study FXR antagonism in vitro and in vivo.

Solvent-Free Selective Hydrogenation of Nitroarenes Using Nanoclusters of Palladium Supported on Nitrogen-Doped Ordered Mesoporous Carbon

The selective hydrogenation of nitroarenes is a key transformation for the production of aromatic amines, which are primary intermediates in the synthesis of pharmaceuticals, agrochemicals, and dyes. However, most reaction processes require toxic organic solvents and suffer from poor selectivity in the presence of other reducible groups. Herein, we report a successful example of nanoclusters of ultrafine Pd supported on N-modified ordered mesoporous CMK-3 carbon (Pd/N-CMK-3) prepared by a facile two-step impregnation route with aqueous solutions of 1,10-phenanthroline and H2PdCl4 that hydrogenated various nitroarenes highly efficiently and selectively to the corresponding aromatic amines with hydrogen in the absence of solvent. The Pd/N-CMK-3 catalyst could be recovered easily for multiple recycling reactions without a loss of catalytic performance.

ANTIVIRAL COMPOUNDS

The present invention provides new antiviral compounds and pharmacological compositions comprising these new compounds and their use in the prophylaxis, prevention and treatment of viral infections, particularly adenovirus and herpes virus infections.