64467-59-0Relevant articles and documents
Secondary amines
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, (2008/06/13)
Methylamine derivatives of the formula: STR1 and pharmaceutically acceptable acid addition salts thereof, wherein R1 and R3 each represent a hydrogen atom or a straight- or branched-chain alkyl, alkenyl or alkynyl radical containing from 1 to 6 carbon atoms, R2 represents a straight- or branched-chain alkyl, alkenyl or alkynyl radical containing from 2 to 7 carbon atoms with the proviso that when R2 represents an alkenyl radical of the formula CH=CH--R6 or an alkynyl radical of the formula C C--R6, in which R6 represents a hydrogen atom or a straight- or branched-chain alkyl radical of 1 to 5 carbon atoms, R1 and R3 each represent an atom of hydrogen or an alkyl radical, R4 and R5, which are the same or different, each respresent a hydrogen atom, a straight- or branched-chain alkyl, alkenyl or alkynyl radical containing from 1 to 5 carbon atoms or an ω-hydroxyalkyl radical containing from 2 to 5 carbon atoms or R4 and R5, when they are taken together represent an alkylene radical containing from 2 to 6 carbon atoms, an alkylidene radical containing from 1 to 5 carbon atoms or the radical --CH2 --CH2 --O--CH2 --CH2 --, R1, R2 and R3 being such that the trisubstituted methylamine radical possesses no more than 13 carbon atoms. They are useful for treating Parkinson's disease and for correcting extra-pyramidal disturbances provoked by neuroleptics.
