64472-06-6Relevant academic research and scientific papers
Short syntheses of (-)-(R)-Pyrrolam A and (1S)-1-hydroxyindolizidin-3-one
Schobert, Rainer,Wicklein, Andre
, p. 1499 - 1502 (2007)
(-)-(R)-Pyrrolam A was prepared in five steps, 95% ee and 25% yield, from (R)-benzyl prolinate. Closure of the pyrrolidine ring was effected by a domino addition-Wittig alkenation reaction with ylide Ph3PCCO, immobilized on a polystyrene resin.
