64481-10-3

Basic information

• Product Name: 6,8-DICHLORO-3-FORMYLCHROMONE
• Synonyms: AKOS BBS-00006650;AKOS B022467;6,8-DICHLOROCHROMONE-3-CARBOXALDEHYDE;6,8-DICHLORO-3-FORMYLCHROMONE;6,8-DICHLORO-4-OXO-4 H-1-BENZOPYRAN-3-CARBOXALDEHYDE;6,8-DICHLORO-4-OXO-4H-CHROMENE-3-CARBALDEHYDE;LABOTEST-BB LT00453344;RARECHEM AK HH 0032
• CAS NO: 64481-10-3
• Molecular Formula: C₁₀H₄Cl₂O₃
• Molecular Weight: 243.04
• Product Categories: Chromones;Coumarin
• Mol File: 64481-10-3.mol
• Article Data: 8

Chemical Properties

• Melting Point: 169-174 °C
• Boiling Point: 396.7 °C at 760 mmHg
• Flash Point: 180.5 °C
• Appearance: Light yellow/Crystalline Powder
• Density: 1.669 g/cm³
• Vapor Pressure: 1.67E-06mmHg at 25°C
• Refractive Index: 1.698
• CAS DataBase Reference: 6,8-DICHLORO-3-FORMYLCHROMONE(CAS DataBase Reference)
• NIST Chemistry Reference: 6,8-DICHLORO-3-FORMYLCHROMONE(64481-10-3)
• EPA Substance Registry System: 6,8-DICHLORO-3-FORMYLCHROMONE(64481-10-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26
• WGK Germany: 3
• Hazardous Substances Data: 64481-10-3(Hazardous Substances Data)

Usage

Chemical Properties

light yellow crystalline powder

InChI:InChI=1/C10H4Cl2O3/c11-6-1-7-9(14)5(3-13)4-15-10(7)8(12)2-6/h1-4H

Upstream product

• 120-83-2 2,4-dichlorophenol 
• 875290-26-9 acetoxy(6,8-dichloro-4-oxo-4H-chromen-3-yl)methyl acetate 
• 3321-92-4 1-(3,5-dichloro-2-hydroxyphenyl)-ethanone 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 478375-85-8 4-[1-(6,8-Dichloro-4-oxo-4H-chromen-3-yl)-meth-(Z)-ylidene]-5-methyl-2-phenyl-2,4-dihydro-pyrazol-3-one 
• 1097213-84-7 C₂₀H₁₁Cl₂N₃O₃ 
• 1253038-70-8 C₁₉H₁₁Cl₂N₃O₃ 
• 1253038-68-4 C₁₇H₁₃Cl₂N₃O₃S 
• 1253038-62-8 C₁₉H₁₁Cl₂N₃O₂ 
• 1253038-63-9 C₁₅H₁₁Cl₂N₃O₂ 
• 1162661-57-5 ethyl 3-(5-(3,5-dichloro-2-hydroxybenzoyl)-2-hydroxyphenyl)-3-oxopropanoate 
• 1162661-47-3 ethyl 3-acetyl-5-(3,5-dichloro-2-hydroxybenzoyl)-2-hydroxybenzoate 
• 1063738-09-9 6,8-dichloro-3-((Z)-2-(4-nitrophenyl)-2-(1H-tetrazol-5-yl)vinyl)-4H-chromen-4-one 
• 1097213-86-9 C₂₇H₂₄BrCl₂N₃O₄ 
• 1097213-81-4 C₂₃H₂₅Cl₂N₃O₄ 

Relevant articles and documents

One pot and metal-free approach to 3-(2-Hydroxybenzoyl)-1-aza-anthraquinones

Herein, a direct strategy to synthesize 3-(2-hydroxybenzoyl)-1-aza-anthraquinones with excellent efficiency,mild conditions, and benign functional group compatibilitywas reported. Avariety of 3-formylchromone compounds were employed as compatible substrates and this protocol gave the 3-(2-hydroxybenzoyl)-1-aza-anthraquinone derivatives in good to excellent yields without inert gas and expensive transition metal catalysts. Some compounds displayed good anti-proliferative activities.

Improved flavodoxin inhibitors with potential therapeutic effects against Helicobacter pylori infection

Helicobacter pylori (Hp) infection affects one-half of the human population and produces a variety of diseases from peptic ulcer to cancer. Current eradication therapies achieve modest success rates (around 70%), resistance to the antibiotics of choice is on the rise, and vaccination has not proved to be successful yet. Using an essential Hp protein, flavodoxin, as target, we identified three low-molecular-weight flavodoxin inhibitors with bactericidal anti-Hp properties. To improve their therapeutic indexes, we have now identified and tested 123 related compounds. We have first tested similar compounds available. Then we have designed, synthesized, and tested novel variants for affinity to flavodoxin, MIC for Hp, cytotoxicity, and bactericidal effect. Some are novel bactericidal inhibitors with therapeutic indexes of 9, 38 and 12, significantly higher than those of their corresponding leads. Developing novel Hp-specific antibiotics will help fighting Hp resistance and may have the advantage of not generally perturbing the bacterial flora.

One-pot synthesis of 3-formylchromones from bis-(trichloromethyl) carbonate/DMF

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