64481-12-5

Usage

Uses

Used in Pharmaceutical Research:
6-Chloro-3-formyl-7-methylchromone is used as a suitable reagent for studying the multidrug resistance reversal by some 3-formylchromones in human colon cancer and mouse lymphoma cells transfected with the human MDR1 gene. Its application in this field is crucial for understanding and potentially overcoming the challenges posed by multidrug resistance in cancer treatment.
Used in Chemical Synthesis:
In the field of chemical synthesis, 6-Chloro-3-formyl-7-methylchromone serves as a suitable reagent for the synthesis of a uridine-based library. This application highlights its utility in the development of new compounds and molecules with potential biological activities and therapeutic applications.

InChI:InChI=1/C11H7ClO3/c1-6-2-10-8(3-9(6)12)11(14)7(4-13)5-15-10/h2-5H,1H3

Upstream product

• 28480-70-8 5'-chloro-2'-hydroxy-4'-methyl acetophenone 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 101618-04-6 6-Chloro-2-ethoxy-7-methyl-3-[1-p-tolylamino-meth-(E)-ylidene]-chroman-4-one 
• 101640-24-8 6-Chloro-3-[1-(4-chloro-phenylamino)-meth-(E)-ylidene]-2-ethoxy-7-methyl-chroman-4-one 
• 101640-23-7 6-Chloro-2-ethoxy-3-[1-(4-methoxy-phenylamino)-meth-(E)-ylidene]-7-methyl-chroman-4-one 
• 101660-29-1 6-Chloro-2-ethoxy-7-methyl-3-[1-phenylamino-meth-(E)-ylidene]-chroman-4-one 
• 909728-14-9 ethyl 3-(3-chloropropyl)-2-hydroxy-5-(2-hydroxy-5-chloro-4-methylbenzoyl)benzoate 
• 1099596-99-2 dimethyl 5-(5-chloro-2-hydroxy-4-methyl-benzoyl)-2-hydroxyisophthalate 
• 1063738-11-3 6-chloro-7-methyl-3-((Z)-2-(4-nitrophenyl)-2-(1H-tetrazol-5-yl)vinyl)-4H-chromen-4-one 
• 1208121-58-7 7-(5'-chloro-2'-hydroxy-4'-methylbenzoyl)-5,6-dimethoxycarbonyl-2,3-dimethyl-8-formyl-5H-[1,3]thiazolo[3,2-a]pyridine 
• 1287736-31-5 trimethyl 5-(2-hydroxy-4-methyl-5-chlorobenzoyl)benzene-1,2,3-tricarboxylate 
• 1369903-15-0 N-((6-chloro-7-methyl-4-oxo-4H-chromen-3-yl)methylene)aniline oxide 

Relevant academic research and scientific papers

One pot and metal-free approach to 3-(2-Hydroxybenzoyl)-1-aza-anthraquinones

Herein, a direct strategy to synthesize 3-(2-hydroxybenzoyl)-1-aza-anthraquinones with excellent efficiency,mild conditions, and benign functional group compatibilitywas reported. Avariety of 3-formylchromone compounds were employed as compatible substrates and this protocol gave the 3-(2-hydroxybenzoyl)-1-aza-anthraquinone derivatives in good to excellent yields without inert gas and expensive transition metal catalysts. Some compounds displayed good anti-proliferative activities.

Thiazolidine-2,4-diones derivatives as PPAR-γ agonists: Synthesis, molecular docking, in vitro and in vivo antidiabetic activity with hepatotoxicity risk evaluation and effect on PPAR-γ gene expression

A library of conjugates of chromones and 2,4-thiazolidinedione has been synthesized by Knoevenagel condensation followed by reduction using hydrogen gas and Pd/C as a catalyst. Compounds 5c and 5e were most effective in lowering the blood glucose level comparable to standard drug pioglitazone. Compound 5e exhibited potent PPAR-γ transactivation of 48.72% in comparison to pioglitazone (62.48%). All the molecules showed good glide score against the PPAR-γ target in molecular docking study. PPAR-γ gene expression was significantly increased by compound 5e (2.56-fold) in comparison to standard drug pioglitazone. Compounds 5e and 5c did not cause any damage to the liver and may be considered as promising candidates for the development of new antidiabetic agents.

2-Hydroxy Ketones, V. --- Preperation of Substituted Chromones

Various 2-hydroxyacetophenone derivatives react with Vilsmeier reagent according to the Harnisch method to give the substituted chromones 2b-i, which have been identified by elemental analyses and IR and 1H-NMR spectra.