64485-89-8

Basic information

• Product Name: ethyl (Z)-alpha-(methoxyimino)-2-(tritylamino)thiazol-4-acetate
• Synonyms: ethyl (Z)-alpha-(methoxyimino)-2-(tritylamino)thiazol-4-acetate;α-[(Z)-Methoxyimino]-2-[(triphenylmethyl)amino]-4-thiazoleacetic acid ethyl ester;(Z)-ethyl 2-(methoxyimino)-2-(2-(tritylamino)thiazol-4-yl)acetate;Cefotaxime Impurity 5
• CAS NO: 64485-89-8
• Molecular Formula: C₂₇H₂₅N₃O₃S
• Molecular Weight: 471.5707
• EINECS: 264-913-8
• Mol File: 64485-89-8.mol
• Article Data: 6

Chemical Properties

• Melting Point: 120 °C(Solv: ethanol (64-17-5))
• Boiling Point: 616.7±65.0 °C(Predicted)
• Appearance: /
• Density: 1.19±0.1 g/cm3(Predicted)
• PKA: 0.81±0.10(Predicted)
• CAS DataBase Reference: ethyl (Z)-alpha-(methoxyimino)-2-(tritylamino)thiazol-4-acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (Z)-alpha-(methoxyimino)-2-(tritylamino)thiazol-4-acetate(64485-89-8)
• EPA Substance Registry System: ethyl (Z)-alpha-(methoxyimino)-2-(tritylamino)thiazol-4-acetate(64485-89-8)

Safety Data

• Hazardous Substances Data: 64485-89-8(Hazardous Substances Data)

Usage

General Description

Ethyl (Z)-alpha-(methoxyimino)-2-(tritylamino)thiazol-4-acetate is a chemical compound with the molecular formula C24H21N3O3S. It is a derivative of thiazol-4-acetate, containing an ethyl group, a methoxyimino group, and a tritylamino group. The compound has potential applications in pharmaceuticals and organic synthesis due to its unique structural features. However, it is important to handle this chemical with care and follow proper safety protocols, as it may pose hazards if not handled properly. Further research and testing may be necessary to determine its full range of properties and potential uses.

Upstream product

• 65872-39-1 (Z)-γ-bromo-β-oxo-α-methoxyiminobutyric acid ethyl ester 
• 67-68-5 dimethyl sulfoxide 
• 66338-99-6 ethyl (Z)-2-hydroxyimino-2-(2-triphenylmethylaminothiazol-4-yl)acetate 
• 74-88-4 methyl iodide 
• 76-83-5 trityl chloride 
• 584-08-7 potassium carbonate 
• 64485-88-7 ethyl 2-(2-aminothiazol-4-yl)-2-(anti)-methoxyiminoacetate 

Downstream Products

• 64485-90-1 2-(2-aminothiazol-4-yl)-2-(methoxy)iminoacetic acid 
• 63527-52-6 cefotaxime 
• 65052-63-3 cefetamet 
• 104146-53-4 7-<(Z)-2-(2-Aminothiazol-4-yl)-2-methoxyiminoacetamido>-3(Z)-(4-methylthiazol-5-yl)vinyl-3-cephem-4-carboxylic acid sodium salt 
• 104146-13-6 p-Methoxybenzyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-methoxyiminoacetamido>-3(E)-(4-methylthiazol-5-yl)vinyl-3-cephem-4-carboxylate 
• 138450-73-4 p-Methoxybenzyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-methoxyiminoacetamido>-3(Z)-(4-methylthiazol-5-yl)vinyl-3-cephem-4-carboxylate 
• 138514-32-6 Pivaloyloxymethyl 7-<(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido>-3(E)-(4-methylthiazol-5-yl)vinyl-3-cephem-4-carboxylate 
• 117467-28-4 cefditoren pivoxil 

Relevant articles and documents

Novel cephalosporin compounds and processes for preparation thereof

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Cephalosporins

Compounds of the formula STR1 wherein R1 is hydrogen or a conventional amino-protecting group, and R2 is a straight or branched chain alkyl group containing from 1 to 4 carbon atoms, allyl, 2-butenyl or 3-butenyl, and nontoxic pharmaceutically acceptable salts and solvates thereof, as well as processes for their preparation, are disclosed. The compounds in which R1 is hydrogen are potent antibacterial agents.

Alkyloximes of 7-amino-thiazolyl-acetamido-cephalosporanic acids

Novel alkyloximes of 7-amino-thiazolyl-acetamidocephalosporanic acids of the formula STR1 wherein R is selected from the group consisting of alkyl of 1 to 5 carbon atoms, cycloalkyl of 3 to 5 carbon atoms and --CH2 --SR', R' is selected from the group consisting of acyl of an alkanoic acid of 2 to 4 carbon atoms, 1-methyl-tetrazolyl and 2-methyl-1,3,4-thiadiazolyl, R1 is selected from the group consisting of hydrogen and a group easily removeable by acid hydrolysis or hydrogenolysis, R2 is selected from the group consisting of alkyl of 1 to 4 carbon atoms and alkenyl and alkynyl of 2 to 4 carbon atoms, A is selected from the group consisting of hydrogen, an alkali metal cation, an equivalent of an alkaline earth metal or magnesium, an organic amine base cation and an ester group easily removeable by acid hydrolysis or hydrogenolysis with the proviso that when R1 is hydrogen, A is not an ester group easily removeable by hydrogenolysis or acid hydrolysis and the wavy line means that OR2 is in one or the other of the two possible syn or anti isomeric positions having a very good antibiotic activity and novel processes and intermediates for their preparation.