64488-19-3

Usage

Molecular structure

1-Benzyl-4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile consists of a complex structure with a benzyl group, two methyl groups, and a carbonitrile functional group.

Chemical class

It belongs to the dihydropyridine class of compounds, which are known for their diverse biological activities and potential applications in pharmaceuticals.

Keto group

The compound has a keto group (C=O) attached to one of the carbon atoms in the ring, which may contribute to its unique reactivity and potential applications in organic synthesis.

Carbonitrile functional group

The presence of a carbonitrile group (C≡N) in the molecule can enhance its reactivity and make it a valuable building block in the synthesis of various organic compounds.

Potential applications

Due to its unique structure and potential reactivity, 1-Benzyl-4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile may have applications in organic synthesis and pharmaceutical research.

Subject of further study

The properties and potential uses of 1-Benzyl-4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile could be the subject of further study and exploration in the field of chemistry and drug development, as it may lead to the discovery of new compounds with therapeutic potential.

Upstream product

• 10412-93-8 N-Benzylcyanoacetamide 
• 123-54-6 acetylacetone 
• 100-44-7 benzyl chloride 
• 769-28-8 3-Cyano-4,6-dimethyl-2(1H)-pyridon 

Downstream Products

• 64487-98-5 1-(benzyl)-3-carboxy-4,6-dimethylpyrid-2-one 

Relevant academic research and scientific papers

Zinc (II)-mediated selective O-benzylation of 2-Oxo-1,2-dihydropyridines systems

The selective O-benzylation of 2-oxo-1,2-dihydropyridines plays a critical role in organic synthesis of natural products and biological active molecules. Herein we report a novel ternary system of ZnO, ZnCl2 and N,N-diisopropylethylamine (DIEA), that is highly effective for selective O-benzylation of 2-oxo-1,2-dihydropyridines using abundant substituted benzyl halides and related substituted 2-oxo-1,2-dihydropyridines compounds. This process allows access to a variety of O-benzyl products under mild reaction conditions, which are important synthetic intermediates in the protection of functional groups, and represents a new method toward the development for the O-benzylation of 2-oxo-1,2-dihydropyridines.

Ionic liquid catalyzed 4,6-disubstituted-3-cyano-2-pyridone synthesis under solvent-free conditions

A green protocol for the synthesis of 4,6-disubstituted-3-cyano-2-pyridones from cyanoacetamides and 1,3-dicarbonyl compounds or chalcones using guanidine based ionic liquid as catalyst has been developed. In solvent-free conditions at 30 °C, [TMG][Lac] (1,1,3,3-tetramethylguanidine lactate) was found to have the highest catalytic activity among the ionic liquids including [TMG][Ac] (1,1,3,3-tetramethylguanidine acetate), [TMG][Pr] (1,1,3,3-tetramethylguanidine propionate), [TMG][n-Bu] (1,1,3,3-tetramethylguanidine n-butyrate) and [TMG][TFA] (1,1,3,3-tetramethylguanidine trifluoroacetate). The catalyst was recovered and recycled several times without significant loss of catalytic activity. Graphical Abstract: [Figure not available: see fulltext.]

Derivatives of 3-carboxy pyrid-2-ones

Novel compounds belonging to the class of 1-substituted benzylpyrid-2-one-4,6-dialkyl and 4,5,6-trisubstituted-3-carboxylic acids, amides, esters and physiologically acceptable salts. These compounds possess biological activity and in particular are gametocides and plant growth regulators. Novel 1-substituted benzyl-3-cyano-4,5,6-trisubstituted pyrid-2-ones are also disclosed as intermediates.