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64490-92-2

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64490-92-2 Usage

Chemical Properties

Crystalline Solid

Uses

Different sources of media describe the Uses of 64490-92-2 differently. You can refer to the following data:
1. Anti-inflammatory
2. Anti-inflammatory.

Definition

ChEBI: An organic sodium salt that is the dihydrate form of tolmetin sodium. Used as a nonselective nonsteroidal anti-inflammatory drug.

Biological Activity

tolmetin is a non-steroidal anti-inflammatory drug that non-selectively inhibits human cox-1 and -2 [1].the cyclooxygenase (cox) is a therapeutic target for preventing cancer. two isoforms of cox have been identified: cox 1 and cox 2. cox 1 has been constitutively expressed in most tissues and involved in mediating production of prostaglandins that control normal physiological functions, such as maintenance of the gastric mucosa and regulation of renal blood flow. cox 2 is undetectable in most normal tissues [2].

in vitro

tolmetin inhibited the activity of human cox-1 and -2 with ic50 values of 0.35 and 0.82 μm, respectively [1]. tolmetin was a competitive and reversible inhibitor of prostaglandin synthetase [3].

in vivo

in rats, pretreatment with tolmetin reduced prostaglandin synthesis by minces of renal medulla. incubation of medullary tissue with tolmetin decreased prostagland production. in anesthetized dogs, tolmetin reduced renal blood flow and shifted the distribution of renal cortical flow from the inner cortex toward the outer cortex [4].

references

[1] warner t d, giuliano f, vojnovic i, et al. nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis[j]. proceedings of the national academy of sciences, 1999, 96(13): 7563-7568.[2] dannenberg a j, altorki n k, boyle j o, et al. cyclo-oxygenase 2: a pharmacological target for the prevention of cancer[j]. the lancet oncology, 2001, 2(9): 544-551.[3] taylor r j, salata j j. inhibition of prostaglandin synthetase by tolmetin (tolectin, mcn-2559), a new non-steroidal anti-inflammatory agent[j]. biochemical pharmacology, 1976, 25(22): 2479-2484.[4] noordewier b, stygles v g, hook j b, et al. effect of tolmetin on renal function and prostaglandin metabolism[j]. journal of pharmacology and experimental therapeutics, 1978, 204(2): 461-468.

Check Digit Verification of cas no

The CAS Registry Mumber 64490-92-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,4,4,9 and 0 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 64490-92:
(7*6)+(6*4)+(5*4)+(4*9)+(3*0)+(2*9)+(1*2)=142
142 % 10 = 2
So 64490-92-2 is a valid CAS Registry Number.
InChI:InChI=1/C15H15NO3.Na.2H2O/c1-10-3-5-11(6-4-10)15(19)13-8-7-12(16(13)2)9-14(17)18;;;/h3-8H,9H2,1-2H3,(H,17,18);;2*1H2/q;+1;;

64490-92-2 Well-known Company Product Price

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  • USP

  • (1670502)  Tolmetin sodium  United States Pharmacopeia (USP) Reference Standard

  • 64490-92-2

  • 1670502-500MG

  • 4,647.24CNY

  • Detail

64490-92-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name Tolmetin Sodium Salt Dihydrate

1.2 Other means of identification

Product number -
Other names sodium,2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetate,dihydrate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:64490-92-2 SDS

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