644961-00-2

Upstream product

• 170564-98-4 (R)-3-amino-3-phenyl-1-propanol 
• 22509-74-6 N-ethoxycarbonylphthalimide 

Downstream Products

• 1386981-92-5 (R)-3-(1,3-dioxoisoindolin-2-yl)-3-phenylpropyl 4-methylbenzenesulfonate 
• 1386981-97-0 (R)-tert-butyl 3-(1,3-dioxoisoindolin-2-yl)-1-phenylpropylcarbamate 
• 1386981-96-9 (R)-2-(3-amino-1-phenylpropyl)isoindoline-1,3-dione 
• 1386981-94-7 (R)-2-(3-azido-1-phenylpropyl)isoindoline-1,3-dione 

Relevant academic research and scientific papers

PYRIDO PYRIMIDINES

Compounds of formula and pharmaceutically acceptable salts thereof are described, as well as the pharmaceutical compositions containing said compounds and their pharmaceutically acceptable salts, and the use of said compounds and pharmaceutical compositions for the treatment, control or amelioration of proliferative diseases, including cancer, Down syndrome or early onset Alzheimer's disease.

Enantioselective hydroformylation of N-vinyl carboxamides, allyl carbamates, and allyl ethers using chiral diazaphospholane ligands

Rhodium complexes of diazaphospholane ligands catalyze the asymmetric hydroformylation of N-vinyl carboxamides, allyl ethers, and allyl carbamates; products include 1,2- and 1,3-aminoaldehydes and 1,3-alkoxyaldehydes. Using glass pressure bottles, short reaction times (generally less than 6 h), and low catalyst loading (commonly 0.5 mol %), 20 substrates are successfully converted to chiral aldehydes with useful regioselectivity and high enantioselectivity (up to 99% ee). Chiral Roche aldehyde is obtained with 97% ee from the hydroformylation of allyl silyl ethers. Commonly difficult substrates such as 1,1- and 1,2-disubstituted alkenes undergo effective hydroformylation with 89-97% ee and complete conversion for six examples. Palladium-catalyzed aerobic oxidative amination of allyl benzyl ether followed by enantioselective hydroformylation yields the β3-aminoaldehyde with 74% ee.