644981-52-2

Upstream product

• 644981-45-3 di-tert-butyl [2R,2(1R)]-2-[2-(tert-butyldiphenylsilyl)oxy-1-[3-(methoxymethoxy)propionyl]oxyethyl]-3-diazo-2-(trimethylsilyl)oxybutanedioate 
• 644981-44-2 di-tert-butyl [2R,2(1R)]-2-[2-(tert-butyldiphenylsilyl)oxy-1-[3-(methoxymethoxy)propionyl]oxyethyl]-3-diazo-2-hydroxybutanedioate 
• 644981-41-9 tert-butyl (2S,3R)-4-(tert-butyldiphenylsilyl)oxy-3-[3-(methoxymethoxy)propionyl]oxy-2-(tetrahydropyran-2-yl)oxybutanoate 
• 644981-39-5 tert-butyl (2S,3R)-4-(tert-butyldiphenylsilyl)oxy-3-(4-methoxybenzyl)oxy-2-(tetrahydropyran-2-yl)oxybutanoate 
• 644981-38-4 tert-butyl (2S,3R)-4-(tert-butyldiphenylsilyl)oxy-2-hydroxy-3-(4-methoxybenzyl)oxybutanoate 
• 644981-42-0 tert-butyl (2S,3R)-4-(tert-butyldiphenylsilyl)oxy-2-hydroxy-3-[3-(methoxymethoxy)propionyl]oxybutanoate 
• 644981-40-8 tert-butyl (2S,3R)-4-(tert-butyldiphenylsilyl)oxy-3-hydroxy-2-(tetrahydropyran-2-yl)oxybutanoate 
• 644981-43-1 tert-butyl (R)-4-(tert-butyldiphenylsilyl)oxy-3-[3-(methoxymethoxy)propionyl]oxy-2-oxobutanoate 
• 644981-36-2 di-tert-butyl (2S,3S)-2-hydroxy-3-(4-methoxybenzyl)oxybutanedioate 
• 644981-37-3 tert-butyl (2S,3R)-2,4-dihydroxy-3-(4-methoxybenzyl)oxybutanoate 
• 207124-07-0 3-(methoxymethoxy)propionic acid 
• 117384-46-0 di-tert-butyl D-tartrate 
• 644981-48-6 di-tert-butyl (1S,3R,4S,5R,6R,7R)-7-acetyl-6-benzyloxy-3-[(tert-butyldiphenylsilyl)oxymethyl]-7-hydroxy-1-[2-(methoxymethoxy)ethyl]-4-(trimethylsilyl)oxy-2,8-dioxabicyclo[3.2.1]octane-4,5-dicarboxylate 
• 925453-59-4 di-tert-butyl (1S,3R,4S,5R,6R,7S)-6-benzyloxy-3-[(tert-butyldiphenylsilyl)oxymethyl]-7-hydroxy-7-(1-hydroxyethyl)-1-[2-(methoxymethoxy)ethyl]-4-(trimethylsilyl)oxy-2,8-dioxabicyclo[3.2.1]octane-4,5-dicarboxylate 

Downstream Products

• 925453-22-1 tri-tert-butyl (1S,3S,4S,5R,6R,7R)-6-benzyloxy-7-(tert-butoxycarbonyl)oxy-1-(formylmethyl)-4-hydroxy-2,8-dioxabicyclo[3.2.1]octane-3,4,5-tricarboxylate 
• 925453-61-8 tri-tert-butyl (1S,3S,4S,5R,6R,7R)-6-benzyloxy-7-(tert-butoxycarbonyl)oxy-4-hydroxy-1-(2-hydroxyethyl)-2,8-dioxabicyclo[3.2.1]octane-3,4,5-tricarboxylate 
• 644981-53-3 tri-tert-butyl (1S,3S,4S,5R,6R,7R)-6-benzyloxy-7-(tert-butoxycarbonyl)oxy-4-hydroxy-1-[2-(methoxymethoxy)ethyl]-2,8-dioxabicyclo[3.2.1]octane-3,4,5-tricarboxylate 

Relevant academic research and scientific papers

Total syntheses of zaragozic acids A and C by a carbonyl ylide cycloaddition strategy

A carbonyl ylide cycloaddition approach to the squalene synthase inhibitors zaragozic acids A and C is described. The carbonyl ylide precursor 8 was synthesized starting from di-tert-butyl D-tartrate (47) via an eleven-step sequence involving the regiosel

Total Synthesis of the Squalene Synthase Inhibitor Zaragozic Acid C by a Carbonyl Ylide Cycloaddition Strategy

Ketal isomers avoided. The unique 2,8-dioxabicyclo[3.2.1 ]octane core of zaragozic acid C (1) was constructed in a Rh-catalyzed 1,3-dipolar cycloaddition of an alkyne to an ester carbonyl ylide. Another feature of this improved synthesis is the constructi