644982-55-8

Usage

Uses

Used in Pharmaceutical Industry:
3-Bromo-5-cyanobenzaldehyde is used as a key intermediate in the synthesis of substituted (homo)piperidines, which serve as NK1 receptor ligands. These ligands are crucial in the development of drugs targeting the neurokinin-1 receptor, playing a significant role in various physiological processes and therapeutic applications, such as pain management and psychiatric disorders.
Used in Organic Synthesis:
3-Bromo-5-cyanobenzaldehyde is utilized as a building block in the preparation of various organic compounds, including pharmaceuticals, agrochemicals, and specialty chemicals. Its unique structure allows for a range of chemical reactions, such as nucleophilic substitution, electrophilic aromatic substitution, and reductive debromination, enabling the creation of diverse chemical entities with potential applications in different industries.

Upstream product

• 24964-64-5 3-Cyanobenzaldehyde 
• 97165-77-0 3,5-dibromobenzonitrile 
• 68-12-2 N,N-dimethyl-formamide 
• 1205515-06-5 3-bromo-5-(hydroxymethyl)benzonitrile 
• 919347-53-8 3-bromo-5-formylbenzamide 
• 56990-02-4 3,5-dibromobenzaldehyde 

Downstream Products

• 644982-56-9 3-bromo-5-(methylamino)benzonitrile 
• 1201403-02-2 5-(3-cyano-5-formylphenyl)-3-[1-(ethylsulfonyl)-4-piperidinyl]-1H-indole-7-carboxamide 

Relevant academic research and scientific papers

HETEROCYCLIC AMIDE COMPOUND

Provided is a heterocyclic amide compound that may have a PRS inhibitory action and is expected to be useful as a prophylactic or therapeutic agent for PRS associated diseases and the like including cancer. A compound represented by the following formula

ISOXAZOLIDINE DERIVED INHIBITORS OF RECEPTOR INTERACTING PROTEIN KINASE 1 (RIPK 1)

The present disclosure relates generally to methods and compositions for preventing or arresting cell death and/or inflammation.

PYRIDONE DERIVATIVES AS NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS

The present invention relates to 2-pyridone derivatives of Formula (I) or (IV) as herein described, compositions containing such compounds, synthetic processes for making such compounds, and therapeutic methods that include the administration of such comp

CHEMICAL COMPOUNDS

The invention is directed to novel indole carboxamide derivatives. Specifically, the invention is directed to compounds according to formula I: where R1, R2, R3, U and V are defined below and to pharmaceutically acceptable salts thereof. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKKβ) activity, such as rheumatoid arthritis, asthma, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

CHEMICAL COMPOUNDS

The present invention relates to cyclic amine derivatives of formula(I) (I)whereinR represents halogen, C1-4 alkyl, cyano, C1-4 alkoxy, trifluoromethyl or trifluoromethoxy;R1 represents hydrogen, halogen, C3-7cycloalkyl, hydroxy, nitro, cyano or C1-4 alkyl optionally substituted by halogen, cyano or C1-4 alkoxy;R2 represents hydrogen or C1-4 alkyl;R3 and R4 independently represent hydrogen, cyano, C1-4 alkyl or R3 together with R4 represents C3-7 cycloalkyl;R5 represents trifluoromethyl, S(O)t C 1-4 alkyl, C1-4 alkyl, C1-4 alkoxy, trifluoromethoxy, halogen or cyano;R6 represents hydrogen or (CH2)rR7;R7 represents hydrogen, C3-7 cycloalkyl, NH(C1-4alkylOC1-4alkoxy), NH(C1-4alkyl), N(C1-4alkyl)2, OC(O)NR9R8, NR8C(O)R9 or C(O)NR9R8;R9 and R8 independently represent hydrogen, C1-4 alkyl or C3-7 cycloalkyl; m represents zero or an integer from 1 to 4;n represents 1 or 2;p is zero or an integer from 1 to 3;q is an integer from 1 to 3;r is an integer from 1 to 4;t is 0, 1 or 2;provided that when m is 0, p is 2, q, r and n represent 1, R1, R2,R3, R4, R5 and R7 are hydrogen and R is chlorine, R5 is not iodine; and pharmaceutically acceptable salts and solvates thereof; process for their preparation and their use in the treatment of conditions mediated by tackykinins and/or by selective inhibition of serotonin reuptake transporter protein.