644989-74-2

Upstream product

• 178977-57-6 tert-butyl (5S,6R,2E,7E)-5-hydroxy-6-methyl-8-phenyl-2,7-octadienoate 
• 350245-09-9 2-(tert-butyl-dimethyl-silanyloxy)-4-methyl-pentanoyl chloride 

Downstream Products

• 644989-77-5 (E)-(3S,10R,16S)-3-Isobutyl-10-(4-methoxy-benzyl)-6,6-dimethyl-16-((E)-(R)-1-methyl-3-phenyl-allyl)-1,4-dioxa-8,11-diaza-cyclohexadec-13-ene-2,5,9,12-tetraone 
• 644989-79-7 (3E)-1-[(2E)-3-(N-{(1R)-2-(3,3-dimethyl-2-oxoazetidin-1-yl)-1-[(4-methoxyphenyl)methyl]-2-oxoethyl}carbamoyl)prop-2-enyl]-(1S,2R)-2-methyl-4-phenylbut-3-enyl (2S)-2-hydroxy-4-methylpentanoate 
• 644989-75-3 (2E,7E)-(5S,6R)-5-((S)-2-Hydroxy-4-methyl-pentanoyloxy)-6-methyl-8-phenyl-octa-2,7-dienoic acid 

Relevant academic research and scientific papers

Synthesis of Cryptophycins via an N-Acyl-β-lactam Macrolactonization

An efficient and concise approach to the synthesis of the macrolide core of the cryptophycins has been developed. A novel macrolactonization utilizing a reactive acyl-β-lactam intermediate incorporates the β-amino acid moiety within the 16-membered macrol