644990-32-9

Upstream product

• 644990-26-1 N⁶-methyl-N⁶-{[2-(4-nitrophenyl)ethoxy]carbonyl}-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)adenosine 
• 161001-99-6 N⁶-methyl-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine 
• 644990-25-0 N⁶-N⁶-{[2-(4-nitrophenyl)ethoxy]carbonyl}-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)adenosine 

Downstream Products

• 644990-28-3 5'-O-{{2-{[5-(dimethylamino)naphthalen-1-yl]sulfonyl}ethoxy}carbonyl}-N⁶-methyl-N⁶-{[2-(4-mitrophenyl)ethoxy]carbonyl}-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)adenosine 

Relevant academic research and scientific papers

Nucleotides: Part LXXII. Synthesis of N-methylated ribonucleosides for RNA synthesis

The synthesis of various N-methylated nucleosides (m6A, m 3C, m4C, m3U) is described. These minor nucleosides can be obtained by simple methylation with diazomethane of [2-(4-nitrophenyl)ethoxy]carbonyl(npeoc)-protected nucleosides. These methylated compounds are easily further derivatized to fit into the scheme of the [2-(dansyl)ethoxy]carbonyl (dnseoc) approach for RNA synthesis (dansyl = [5-(dimethylamino)naphthalen-1-yl]sulfonyl). Various oligoribonucleotides containing N6-methyladenosine were synthesized, underlining the usefulness of the dnseoc approach, especially for the synthesis of natural tRNA-derived oligoribonucleotide sequences.