644995-09-5

Basic information

• Product Name: (S)-3-(4-amino-phenyl)-2-(3-oxo-spiro[3.5]non-1-en-1-ylamino)-propionic acid ethyl ester
• Synonyms: (S)-3-(4-amino-phenyl)-2-(3-oxo-spiro[3.5]non-1-en-1-ylamino)-propionic acid ethyl ester
• CAS NO: 644995-09-5
• Molecular Weight: 342.438
• Mol File: 644995-09-5.mol

Chemical Properties

• CAS DataBase Reference: (S)-3-(4-amino-phenyl)-2-(3-oxo-spiro[3.5]non-1-en-1-ylamino)-propionic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-(4-amino-phenyl)-2-(3-oxo-spiro[3.5]non-1-en-1-ylamino)-propionic acid ethyl ester(644995-09-5)
• EPA Substance Registry System: (S)-3-(4-amino-phenyl)-2-(3-oxo-spiro[3.5]non-1-en-1-ylamino)-propionic acid ethyl ester(644995-09-5)

Safety Data

• Hazardous Substances Data: 644995-09-5(Hazardous Substances Data)

Upstream product

• 644995-08-4 3-(4-nitrophenyl)-2(S)-(3-oxospiro[3.5]non-1-en-1-ylamino)propionic acid ethyl ester 

Downstream Products

• 455264-29-6 UC⁽⁹³³⁾B₁₁₉₄ 
• 1031337-80-0 ethyl 4-[(4-fluoro-2-nitrophenyl)amino]-N-(3-oxospiro[3.5]non-1-en-1-yl)-L-phenylalaninate 
• 1031337-82-2 ethyl 4-[(3-nitropyridin-4-yl)amino]-N-(3-oxospiro[3.5]non-1-en-1-yl)-L-phenylalaninate 

Relevant articles and documents

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PROCESS FOR THE PREPARATION OF PHENYLALANINE ENAMIDE DERIVATIVES

A process for the preparation of a class of phenylalanine enamide derivatives is described formula (1) wherein: Ar1 is an optionally substituted aromatic or heteroaromatic group; L2 is a linker group selected from -N(R4)- [where R4 is a hydrogen atom or an optionally substituted straight or branched C1-6alkyl group], -CON(R4)-, or -S(O)2N(R4)-; R1 is a carboxylic acid (-CO2H) or a derivative or biostere thereof; R2 is a hydrogen atom or a C1-6alkyl group; Rx, Ry and Rz which may be the same or different is each an atom or group -L1(Alk1)n(R3)v; and the salts, solvates, hydrates and N-oxides thereof; which comprises reacting a compound of formula (2): wherein: Qa is a group -N(R4)H; and the salts, solvates, hydrates and N-oxides thereof; with a compound Ar1W wherein W is a group selected from X1 (wherein X1 is a leaving atom or group), -COX2 (wherein X2 is a halogen atom or a -OH group) or -SO2 X3 (in which X3 is a halogen atom).