644996-23-6

Basic information

• Product Name: N-[2-[(benzyloxycarbonyl)amino]ethyl]-3(R)-[(tert-butoxycarbonyl)amino]pyrrolidin-2-one
• Synonyms: N-[2-[(benzyloxycarbonyl)amino]ethyl]-3(R)-[(tert-butoxycarbonyl)amino]pyrrolidin-2-one
• CAS NO: 644996-23-6
• Molecular Weight: 377.44
• Mol File: 644996-23-6.mol

Chemical Properties

• CAS DataBase Reference: N-[2-[(benzyloxycarbonyl)amino]ethyl]-3(R)-[(tert-butoxycarbonyl)amino]pyrrolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-[(benzyloxycarbonyl)amino]ethyl]-3(R)-[(tert-butoxycarbonyl)amino]pyrrolidin-2-one(644996-23-6)
• EPA Substance Registry System: N-[2-[(benzyloxycarbonyl)amino]ethyl]-3(R)-[(tert-butoxycarbonyl)amino]pyrrolidin-2-one(644996-23-6)

Safety Data

• Hazardous Substances Data: 644996-23-6(Hazardous Substances Data)

Upstream product

• 18807-71-1 benzyl N-(2-aminoethyl)carbamate hydrochloride 
• 5241-66-7 (R)-N-(tert-butoxycarbonyl)methionine 
• 644996-22-5 N¹-[N-(tert-butoxycarbonyl)-D-methionyl]-N²-(benzyloxycarbonyl)ethane-1,2-diamine 

Downstream Products

• 644996-24-7 N-[2-[(benzyloxycarbonyl)amino]ethyl]-3(R)-[[1-(benzyloxycarbonyl)-2(S)-pyrrolidinylcarbonyl]amino]pyrrolidin-2-one 

Relevant articles and documents

iso-Lactam and reduced amide analogues of the peptidomimetic dopamine receptor modulator 3(R)-[(2(S)-Pyrrolidinylcarbonyl)amino]-2-oxo-1-pyrrolidineacetamide

An analogue of the highly potent γ-lactam Pro-Leu-Gly-NH2 peptidomimetic, 3(R)-[(2(S)-pyrrolidinylcarbonyl) amino]-2-oxo-1-pyrrolidineacetamide (2), 4(R)-[[2(S)-pyrrolidinylcarbonyl]amino]-2-oxo-1-pyrrolidineacetamide (3), in which the lactam carbonyl moiety has been placed in a different position with respect to the 3-amino group was synthesized. Also, a series of analogues of 2, compounds 4-6, were synthesized in which each of the amide bonds of 2 were systematically replaced with a reduced amide bond surrogate. The analogues were tested for their ability to enhance the binding of [ 3H]N-propylnorapomorphine to dopamine receptors in a functional in vitro assay utilizing bovine striatal membranes. Peptidomimetic 3 was shown to be more potent than 2, while 4 and 5 were significantly less effective than 2. Peptidomimetic 6 had a pharmacological profile similar to that of 2.