645-72-7Relevant articles and documents
Comparison of the supramolecular structures of two glyco lipids with chiral and nonchiral methyl-branched alkyl chains from natural sources
Milkereit, G?tz,Garamus, Vasil M.,Yamashita, Jun,Hato, Masakatsu,Morr, Michael,Vill, Volkmar
, p. 1599 - 1608 (2005)
Two alkyl glycosides with the same type of disaccharide headgroups (melibiose) and different methyl-branched alkyl chains, short chiral [(2R,4R,6R,8R)-2,4,6,8-tetramethyldecyl, extracted from an animal source] and long nonchiral (3,7,11,15-tetramethylhexadecyl, from a plant source), were synthesized. The supramolecular aggregate structure formed in dilute solutions was investigated by small-angle neutron scattering and surface tension measurements. The lyotropic phase diagram was studied by differential scanning calorimetry and water penetration scans. The thermotropic phase behavior was investigated by polarizing microscopy. The compounds showed unusual phase behavior: (i) The liquid-crystalline polymorphism is reduced to only form smectic A phases in the pure state; the formation of lyotropic phases such as hexagonal or lamellar phases was not observed, (ii) The compound with the longer nonchiral alkyl chain is more soluble in water than the one with the shorter chiral chain, most likely because of the different flexibilities of the chains, (iii) For the long-chain compound, the formation of micelles is observed, whereas the short-chain compound forms large disklike/bilayer aggregates. The method of methylation of the chain controls the self-assembly and can explain different biological functions for either plants (variable temperature) or animals (constant temperature).
Phosphoramidite reagent and applications thereof in oligonucleotide synthesis
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Paragraph 0198; 0201; 0202, (2020/05/02)
The invention provides a phosphoramidite reagent and applications thereof. According to the invention, the phosphoramidite reagent is a 2-nitrile ethoxy phosphoramidite compound with a large non-polarsubstituent group on a 2-nitrile ethoxy group, and can react with a nucleoside monomer or a nucleotide fragment 3'-OH or 5'-OH to generate phosphoramidite diester, the phosphoramidite diester continuously reacts with another group of nucleoside monomers or nucleotide fragments 3'-OH or 5'-OH under the action of a proper activating agent to generate phosphoramidite trimester, oxidizing or vulcanizing is performed to obtain phosphoric acid triester or thiophosphoric acid trimester, and deprotection is performed to obtain oligonucleotides, wherein in the whole process, all phosphite intermediates or phosphate intermediates are easily dissolved in a solvent with medium and low polarity and have low solubility in a high-polar solvent while other reaction raw materials or by-products are easilydissolved in the high-polar solvent, such that the purification can be performed through non-polar/polar solvent extraction so as not to hinder the subsequent chain propagation reaction; the method is suitable for one-by-one nucleotide linking and reactions linked by a fragment method.
COMPOSITIONS IN THE FORM OF AN INJECTABLE AQUEOUS SOLUTION COMPRISING AMYLIN, AN AMYLIN RECEPTOR AGONIST OR AN AMYLIN ANALOGUE AND A CO-POLYAMINO ACID
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Paragraph 1037-1040, (2019/09/20)
A composition in the form of an injectable aqueous solution, the pH of which is comprised from 6.0 to 8.0, including at least: a) amylin, an amylin receptor agonist or an amylin analogue;b) a co-polyamino acid bearing carboxylate charges and hydrophobic radicals Hy, said co-polyamino acid being constituted of glutamic or aspartic units and said hydrophobic radicals Hy being according to formula I below: [in-line-formulae]*?GpR?r?GpA?a?GpC)p ??Formula I[/in-line-formulae] wherein the composition does not comprise a basal insulin the isoelectric point pI of which is comprised from 5.8 to 8.5. It also relates to a composition wherein it further includes prandial insulin.
INJECTABLE SOLUTION AT PH 7 COMPRISING AT LEAST ONE BASAL INSULIN WHEREIN THE PI IS COMPRISED FORM 5.8 TO 8.5 AND A CO-POLYAMINO ACID BEARING CARBOXYLATE CHARGES AND HYDROPHOBIC RADICALS
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Paragraph 1268; 1269; 1270; 1271, (2019/09/20)
In one embodiment, the composition according to the invention is characterized in that the co-polyamino acid bearing carboxylate charges and at least one hydrophobic radical -Hy is chosen among the co-polyamino acids according to formula XXXb hereinafter: wherein, D represents, independently, either a group —CH2— (aspartic acid) or a group —CH2—CH2— (glutamic acid),X represents a cationic entity chosen in the group comprising alkali cations,Rb and Rb′, identical or different, are either a hydrophobic radical -Hy, or a radical chosen in the group consisting of an H, a C2 to C10 linear acyl group, a C3 to C10 branched acyl group, a benzyl, a terminal “amino acid” unit and a pyroglutamate, at least one of Rb and R′b is a hydrophobic radical -Hy,Q and Hy are as defined above.n+m represents the degree of polymerization DP of the co-polyamino acid, namely the mean number of monomeric units per co-polyamino acid chain and 5≤n+m≤250.
