645-84-1

Basic information

• Product Name: 2-(trimethylammonio)ethyl hydrogen phosphate
• Synonyms: Ethanaminium, N,N,N-trimethyl-2-(phosphonooxy)-, inner salt
• CAS NO: 645-84-1
• Molecular Formula: C₅H₁₄NO₄P
• Molecular Weight: 183.1427
• Mol File: 645-84-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(trimethylammonio)ethyl hydrogen phosphate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(trimethylammonio)ethyl hydrogen phosphate(645-84-1)
• EPA Substance Registry System: 2-(trimethylammonio)ethyl hydrogen phosphate(645-84-1)

Safety Data

• Hazardous Substances Data: 645-84-1(Hazardous Substances Data)

Usage

Phosphorus-containing compound

Contains a phosphate group (PO4) bonded to a carbon chain.

Positively charged

Trimethylammonium group (N+(CH3)3)

Negatively charged

Phosphate group (PO4-)

Buffer

Used to maintain a stable pH level in biochemical and pharmaceutical solutions.

Stabilizer

Helps maintain the stability and integrity of biomolecules in various applications.

Drug production

Component in the synthesis of certain pharmaceutical compounds.

Cosmetic component

Included in some cosmetic formulations for its stabilizing and buffering properties.

Environmental remediation

Potential use in the treatment and cleanup of contaminated environments, such as water and soil.

Catalyst

2-(trimethylammonio)ethyl hydrogen phosphate has been studied for its potential as a catalyst in organic synthesis reactions, promoting and accelerating chemical transformations.

Upstream product

• 3436-44-0 1,2-didecanoyl-sn-glycero-3-phosphocholine 
• 4826-71-5 phosphorylcholine chloride, calcium salt 
• 30115-52-7 [2-(hydroxy-morpholin-4-yl-phosphinoyloxy)-ethyl]-trimethyl-ammonium betaine 

Downstream Products

• 17364-16-8 1-palmitoyl-sn-glycero-3-phosphocholine 
• 72490-82-5 2-hydroxy-3-(octadecyloxy)propyl 2-(trimethylammonio)ethyl phosphate 
• 78119-19-4 2-hydroxy-3-(hexadecyloxy)-propyl 2-trimethylammonioethyl phosphate 
• 74389-69-8 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine 
• 85405-05-6 1-O-hexadecyl-2-O-methylglycero-3-phosphocholine 
• 74430-89-0 Lyso-platelet-activating factor (C₁₈) 

Relevant articles and documents

Conjugated polyelectrolyte based real-time fluorescence assay for phospholipase C

A fluorescence turnoff assay for phospholipase C (PLC) from Clostridium perfringens is developed based on the reversible interaction between the natural substrate, phosphatidylcholine, and a fluorescent, water-soluble conjugated polyelectrolyte (CPE). The fluorescence intensity of the CPE in water is increased substantially by the addition of the phospholipid due to the formation of a CPE-lipid complex. Incubation of the CPE-lipid complex with the enzyme PLC causes the fluorescence intensity to decrease (turnoff sensor); the response arises due to PLC-catalyzed hydrolysis of the phosphatidylcholine, which effectively disrupts the CPE-lipid complex. The PLC assay operates with phospholipid substrate concentrations in the micromolar range, and the analytical detection limit for PLC is 2+ and inhibition by EDTA and fluoride ion are demonstrated using the optimized sensor.