64505-79-9

Basic information

• Product Name: 1,4-Naphthalenedione, 2-chloro-3-[(3-methoxyphenyl)amino]-
• CAS NO: 64505-79-9
• Molecular Formula: C17H12ClNO3
• Molecular Weight: 313.74
• Mol File: 64505-79-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1,4-Naphthalenedione, 2-chloro-3-[(3-methoxyphenyl)amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Naphthalenedione, 2-chloro-3-[(3-methoxyphenyl)amino]-(64505-79-9)
• EPA Substance Registry System: 1,4-Naphthalenedione, 2-chloro-3-[(3-methoxyphenyl)amino]-(64505-79-9)

Safety Data

• Hazardous Substances Data: 64505-79-9(Hazardous Substances Data)

Upstream product

• 117-80-6 2,3-Dichloro-1,4-naphthoquinone 
• 536-90-3 m-Anisidine 

Downstream Products

• 95612-81-0 N-(3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-N-(3-methoxyphenyl)acetamide 
• 1355255-08-1 4-[3-(N-acetyl-3-methoxyphenylamino)-1,4-dioxo-1,4-dihydronaphthalen-2-yl]-1,1-dimethylpiperazinium iodide 
• 1355255-07-0 4-[3-(3-methoxyphenylamino)-1,4-dioxo-1,4-dihydronaphthalen-2-yl]-1,1-dimethylpiperazinium iodide 
• 892230-32-9 2-(3-methoxyphenylamino)-3-(4-methylpiperazin-1-yl)-1,4-dihydronaphthalene-1,4-dione 
• 1355255-11-6 N-(3-methoxyphenyl)-N-[3-(4-methylpiperazin-1-yl)-1,4-dioxo-1,4-dihydronaphthalen-2-yl]acetamide 

Relevant articles and documents

Synthesis and cytotoxicity of 6,11-Dihydro-pyrido- and 6,11-Dihydro-benzo[2,3-b]phenazine-6,11-dione derivatives

6,11-Dihydro-pyrido[2,3-b]phenazine-6,11-diones and 6,11-dihydro-benzo[2,3-b]phenazine-6,11-diones were synthesized from 6,7-dichloro-5,8-quinolinedione and 2,3-dichloro-1,4-naphthoquinone. The study on the cytotoxicity on these products revealed that the pyridophenazinediones, tetracyclic heteroquinone analogues with three nitrogen atoms exhibited a high cytotoxicity on several human tumor cell lines. Compound 9c and 9e showed in vitro antitumor activity comparable or superior to doxorubicin against the human ovarian tumor cells (SK-OV-3) and the human CNS cells (XF 498). The IC50 value for compound 9e was 0.06 μM against the human CNS cells (XF 498), which was 2.6 times higher than that (0.16 μM) of doxorubicin. In addition, the X-ray crystallographic analysis of two phenazinedione derivatives (9b,c) showed clearly the exact position of the nucleophilic substitution of 6,7-dichloro-5,8-quinolinedione.