Cas 645059-89-8,(5-benzo[1,3]dioxol-5-yl-1-dimethylcarbamoylmethyl-2-oxo-2,3-dihydro-1<i>H</i>-benzo[<i>e</i>][1,4]diazepin-3-yl)-carbamic acid benzyl ester

645059-89-8

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Basic information

Product Name: (5-benzo[1,3]dioxol-5-yl-1-dimethylcarbamoylmethyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-carbamic acid benzyl ester
Synonyms:
CAS NO:645059-89-8
Molecular Formula:
Molecular Weight: 514.538
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: (5-benzo[1,3]dioxol-5-yl-1-dimethylcarbamoylmethyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-carbamic acid benzyl ester(CAS DataBase Reference)
NIST Chemistry Reference: (5-benzo[1,3]dioxol-5-yl-1-dimethylcarbamoylmethyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-carbamic acid benzyl ester(645059-89-8)
EPA Substance Registry System: (5-benzo[1,3]dioxol-5-yl-1-dimethylcarbamoylmethyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-carbamic acid benzyl ester(645059-89-8)

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RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 645059-89-8(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 645059-89-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,4,5,0,5 and 9 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 645059-89:
(8*6)+(7*4)+(6*5)+(5*0)+(4*5)+(3*9)+(2*8)+(1*9)=178
178 % 10 = 8
So 645059-89-8 is a valid CAS Registry Number.

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645059-89-8Relevant academic research and scientific papers

High affinity, bioavailable 3-amino-1,4-benzodiazepine-based γ-secretase inhibitors

Owens, Andrew P.,Nadin, Alan,Talbot, Adam C.,Clarke, Earl E.,Harrison, Timothy,Lewis, Huw D.,Reilly, Michael,Wrigley, Jonathan D. J.,Castro, Jose L.

, p. 4143 - 4145 (2003)

In this paper, we describe the development of a novel series of high affinity, orally bioavailable 3-amino-1,4 benzodiazepine-based γ-secretase inhibitors for the potential treatment of Alzheimer's disease. We disclose structure-activity relationships based around the 1, 3 and 5 positions of the benzodiazepine core structure.

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