64512-89-6Relevant articles and documents
Carbonylhydrazide-based molecular tongs inhibit wild-type and mutated HIV-1 protease dimerization
Dufau, Laure,Marques Ressurrei??o, Ana Sofia,Fanelli, Roberto,Kihal, Nadjib,Vidu, Anamaria,Milcent, Thierry,Soulier, Jean-Louis,Rodrigo, Jordi,Desvergne, Audrey,Leblanc, Karine,Bernadat, Guillaume,Crousse, Benoit,Reboud-Ravaux, Micheèle,Ongeri, Sandrine
experimental part, p. 6762 - 6775 (2012/10/08)
We have designed and synthesized new molecular tongs based on a rigid naphthalene scaffold and evaluated their antidimer activity on HIV-1 protease (PR). We inserted carbonylhydrazide and oligohydrazide (azatide) fragments into their peptidomimetic arms t
SYNTHESIS OF A NON-SYMMETRIC AZODICARBONYL COMPOUND AND ITS REGIOSELECTIVE REACTION WITH ORGANOMETALLIC REAGENTS
Yamamoto, Yoshinori,Yumoto, Masatoshi,Yamada, Jun-ichi
, p. 3079 - 3082 (2007/10/02)
The non-symmetric azodicarbonyl compound 7 reacted with R-M/Lewis acid regioselectively at the nitrogen atom attached to the amide group giving 9, whereas it reacted with R-M at the nitrogen atom attached to the ester group producing 8 in high yield.