64516-58-1

Upstream product

• 64516-57-0 4,4-Diphenyl-tetrahydro-pyran-2,6-diol 
• 3531-26-8 3,3-Diphenylglutarsaeure-diethylester 

Downstream Products

• 110454-63-2 (5aR,11aS)-7,7-Diphenyl-1,3,4,6,7,11a-hexahydro-2H,5aH-dipyrido[1,2-a;1',2'-c]imidazol-11-one 
• 110392-31-9 (5aR,11aR)-7,7-Diphenyl-1,3,4,6,7,11a-hexahydro-2H,5aH-dipyrido[1,2-a;1',2'-c]imidazol-11-one 
• 110454-64-3 (2R,9R)-4,4-Diphenyl-1,7-diaza-tricyclo[7.3.1.0^2,7]tridec-5-en-8-one 
• 110392-28-4 (2R,9S)-4,4-Diphenyl-1,7-diaza-tricyclo[7.3.1.0^2,7]tridec-5-en-8-one 
• 131497-69-3 cis-diphenylcyclopentane-1,2-diol 
• 115932-93-9 1-benzoyl-1,4-dihydro-4,4-diphenylpyridine 
• 123412-11-3 1-[2-(3,4-Dimethoxy-phenyl)-ethyl]-4,4-diphenyl-1,4-dihydro-pyridine 
• 115932-97-3 1,4-dihydro-N,N-dimethyl-4,4-diphenyl-1-pyridineethanamine 
• 115932-95-1 1,4-dihydro-N-methyl-4,4-diphenyl-1-pyridinecarboxamide 
• 36666-03-2 4,4-diphenylcyclopent-1-ene 
• 131497-72-8 (3aS,6aR)-2-Methoxy-5,5-diphenyl-tetrahydro-cyclopenta[1,3]dioxole 
• 115933-03-4 1-[(dimethylamino)acetyl]-1,4-dihydro-4,4-diphenylpyridine 

Relevant academic research and scientific papers

Antihypertensive dihydropyridines with 1,4,4-trisubstitution

Dihydropyridines with 1,4,4-trisubstitution were synthesized and tested for antihypertensive activity in a spontaneously hypertensive rat model. This substitution pattern on the dihydropyridine nucleus differs markedly from that found most active in the structure-activity relationship established for nifedipine-like compounds. However, some were found to significantly lower blood pressure at testing doses (30 mg/kg, ip and 100 mg/kg, po) for up to 24 h. Methyl 1,4-dihydro-4,4-dimethyl-1-pyridinepropanoate (2-1), for example, lowered blood pressure 71 mmHg at 30 mg/kg, ip and the effect endured for greater than 24 h. Unlike prototypical dihydropyridines such as nifedipine, these compounds did not seem to have any effect on calcium channels.

An Efficient Synthesis of 4,4-Diphenylcyclopentene

A useful preparative route to 4,4-diphenylcyclopentene 1 is described.

Dihydropyridine compounds having 1,4,4-trisubstitution useful as antihypertensive agents

Dihydropyridine compounds having 1,4,4-trisubstitution of the following formula (I): STR1 wherein R is one of --COR3, R3 being a group such as phenyl or benzyl; R4 where R4 is a heterocycle; --(CH2)n NR5 R6, with R5 and R6 being alkyl or joined to define a ring; or --(CH2)n COOR7, with R7 being alkyl or benzyl. R1 and R2 are alkyl, phenyl or substituted phenyl. The compounds are useful for the treatment of hypertension in mammals, e.g., in humans.