64520-24-7

Basic information

• Product Name: (+)-dihydrocodeinone
• Synonyms: (+)-dihydrocodeinone
• CAS NO: 64520-24-7
• Molecular Weight: 299.37
• Mol File: 64520-24-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (+)-dihydrocodeinone(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-dihydrocodeinone(64520-24-7)
• EPA Substance Registry System: (+)-dihydrocodeinone(64520-24-7)

Safety Data

• Hazardous Substances Data: 64520-24-7(Hazardous Substances Data)

Upstream product

• 467-13-0 dihydrocodeinone 
• 65494-41-9 7,8-dihydrosinomenine 
• 871951-77-8 2-Bromo-6-methoxy-3-((E)-2-phenylsulfanyl-vinyl)-phenol 
• 871951-80-3 N-[2-(2-bromo-3-oxo-cyclohex-1-enyl)-ethyl]-4,N-dimethyl-benzenesulfonamide 

Downstream Products

• 847-86-9 Dihydrothebainon 
• 64470-97-9 ent-4,5α-epoxy-3-methoxy-6-oxo-7β-phenylselanyl-morphinane-17-carboxylic acid ethyl ester 

Relevant articles and documents

Enantioselective synthesis of (-)-dihydrocodeinone: A short formal synthesis of (-)-morphine

The radical cyclization approach to the morphine alkaloids has been applied in an asymmetric synthesis of (-)-dihydrocodeinone. A chiral cyclohexenol (R-32), from the CBS reduction of the enone, is the source of chirality. The first key step, tandem closure in which stereochemistry is controlled by geometric constraints, (-)-15b → (+)-16, was followed by an unprecedented reductive hydroamination, completing the synthesis of (-)-dihydroisocodeine ((-)-17) in 13 steps from commercially available materials.

Studies in the (+)-morphinan series. 7. Unusual crystallographic and tautomeric properties of (+)-4-hydroxy-7-oxo-3-methoxy-17-methyl-5,6-dehydromorphinan: An interlacing double helix

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