645389-93-1

Basic information

• Product Name: Cyclopentanone, 2-[4-(phenylmethoxy)butylidene]-4-[[tris(1-methylethyl)silyl]oxy]-, (2E,4R)-
• CAS NO: 645389-93-1
• Molecular Formula: C25H40O3Si
• Molecular Weight: 416.676
• Mol File: 645389-93-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Cyclopentanone, 2-[4-(phenylmethoxy)butylidene]-4-[[tris(1-methylethyl)silyl]oxy]-, (2E,4R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopentanone, 2-[4-(phenylmethoxy)butylidene]-4-[[tris(1-methylethyl)silyl]oxy]-, (2E,4R)-(645389-93-1)
• EPA Substance Registry System: Cyclopentanone, 2-[4-(phenylmethoxy)butylidene]-4-[[tris(1-methylethyl)silyl]oxy]-, (2E,4R)-(645389-93-1)

Safety Data

• Hazardous Substances Data: 645389-93-1(Hazardous Substances Data)

Upstream product

• 645389-91-9 (4R)-(+)-1-triethylsiloxy-4-triisopropylsilyloxy-cyclopentene 
• 115074-48-1 (1R,4S)-(-)-4-triisopropylsilyloxy-2-cyclopenten-1-ol acetate 
• 645389-89-5 (4S)-(-)-4-triisopropylsilyloxy-2-cyclopenten-1-one 
• 645390-09-6 (1R,4S)-(-)-4-triisopropylsilyloxy-1-hydroxycyclopent-2-ene 
• 60410-16-4 (1R,4S)-4-hydroxy-2-cyclopentene-1-yl acetate 
• 13154-24-0 triisopropylsilyl chloride 
• 645390-11-0 (3R)-5-(4'-benzyloxy-1'-hydroxybutyl)-3-triisopropylsiloxycyclopentanone 

Downstream Products

• 386285-44-5 (2R,4S,9aS)-2-hydroxy-4-(3,4-dimethoxyphenyl)-decahydroquinolizidine 
• 645390-02-9 4-(1-aza-4-triisopropylsilyloxy-bicyclo[4.4.0]dec-2-yl)-1,2-dimethoxybenzene 
• 645389-99-7 (2S,4R)-(+)-4-triisopropylsiloxy-2-(4'-N,O-di(benzyloxycarbonyl)hydroxylaminobutyl)cyclopentan-1-one 

Relevant articles and documents

Ring Expansive Routes to Quinolizidine Alkaloids: Formal Synthesis of (-)-Lasubine II

(Equation presented) The application of two nitrogen ring expansion reactions to lasubine alkaloid synthesis is reported. The approach involves a conjugate reduction/ alkylation sequence carried out on triisopropylsilyl- protected (S)-4-(-)-hydroxycyclopentenone, the formation of the quinolizidone ring system through nitrogen ring expansion, and the addition of an arylmetallic species to the resulting lactam. This work resulted in the preparation of 2-epA-lasubine II and a formal synthesis of lasubine II.