645395-86-4

Upstream product

• 645395-85-3 C₂₅H₂₆N₂O 
• 146621-91-2 2-(tert-butoxycarbonylamino)-2-(naphthalen-1-yl)acetic acid 
• 370561-84-5 methyl 2-diazo-2-(naphthalen-1-yl)acetate 
• 2876-78-0 methyl 1-naphthylacetate 
• 1379796-52-7 (RS)-N-benzyl 2-(t-butoxycarbonylamino)-2-(naphthalen-1-yl)acetamide 
• 896132-09-5 (+/-)-N-tert-butoxycarbonyl-α-1-naphthylglycine methyl ester 

Downstream Products

• 1379796-25-4 (RS)-N-benzyl 2-amino-2-(naphthalen-1-yl)acetamide hydrochloride 

Relevant academic research and scientific papers

Synthesis, anticonvulsant activity, and neuropathic pain-attenuating activity of N-benzyl 2-amino-2-(hetero)aromatic acetamides

N-Benzyl 2-acetamido-2-substituted acetamides, where the 2-substituent is a (hetero)aromatic moiety, are potent anticonvulsants. We report the synthesis and whole animal pharmacological evaluation of 16 analogues where the terminal 2-acetyl group was removed to give the corresponding primary amino acid derivatives (PAADs). Conversion to the PAAD structure led to a substantial drop in seizure protection in animal tests, demonstrating the importance of the N-acetyl moiety for anticonvulsant activity. However, several of the PAADs displayed notable pain-attenuating activities in a mouse model.

Amino amides, peptides and peptidomimetics

Synthetic methods and compounds involving amino amides, peptides and peptidomimetics. Amino amide derivatives are prepared via the one-step three-component reaction of a glyoxamide, an amine, and an organoboron derivative. Conversion of the product to another glyoxamide intermediate allows the iterative use of this chemistry for the synthesis of peptides and peptidomimetics.