645404-79-1Relevant articles and documents
Design, Synthesis, and Bioactivities of Steroid-Linked Taxol Analogues as Potential Targeted Drugs for Prostate and Breast Cancer
Liu, Changhui,Strobl, Jeannine S.,Bane, Susan,Schilling, Jennifer K.,McCracken, Meredith,Chatterjee, Sabarni K.,Rahim-Bata, Rayhana,Kingston, David G. I.
, p. 152 - 159 (2004)
The female steroid hormone 3,17β-estradiol (2) was selected as an agent to target taxol (1) to estrogen receptor (ER) positive breast cancer cells. Estradiol-taxol conjugates (ETC) were synthesized through linkages from the 11- or 16-position of estradiol