64544-16-7

Basic information

• Product Name: N-(2-morpholin-4-ylethyl)-4-(trifluoromethyl)benzamide
• CAS NO: 64544-16-7
• Molecular Formula: C₁₄H₁₇F₃N₂O₂
• Molecular Weight: 302.2922
• Mol File: 64544-16-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 422°C at 760 mmHg
• Flash Point: 209°C
• Density: 1.236g/cm³
• Vapor Pressure: 2.49E-07mmHg at 25°C
• Refractive Index: 1.493
• CAS DataBase Reference: N-(2-morpholin-4-ylethyl)-4-(trifluoromethyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-morpholin-4-ylethyl)-4-(trifluoromethyl)benzamide(64544-16-7)
• EPA Substance Registry System: N-(2-morpholin-4-ylethyl)-4-(trifluoromethyl)benzamide(64544-16-7)

Safety Data

• Hazardous Substances Data: 64544-16-7(Hazardous Substances Data)

Upstream product

• 402-43-7 p-trifluoromethylphenyl bromide 

Relevant articles and documents

Amide Synthesis by Nickel/Photoredox-Catalyzed Direct Carbamoylation of (Hetero)Aryl Bromides

Herein, we report a one-electron strategy for catalytic amide synthesis that enables the direct carbamoylation of (hetero)aryl bromides. This radical cross-coupling approach, which is based on the combination of nickel and photoredox catalysis, proceeds at ambient temperature and uses readily available dihydropyridines as precursors of carbamoyl radicals. The method's mild reaction conditions make it tolerant of sensitive-functional-group-containing substrates and allow the installation of an amide scaffold within biologically relevant heterocycles. In addition, we installed amide functionalities bearing electron-poor and sterically hindered amine moieties, which would be difficult to prepare with classical dehydrative condensation methods.