64563-80-0Relevant academic research and scientific papers
Copper-Phosphine Mediated Oxidative Phosphorylation of Aromatic Amines and P(OR)3 under Aerobic Conditions
Wang, Shihaozhi,Ma, Shidi,Yang, Jiale,Li, Wenshuang,Li, Dianjun,Yang, Jinhui
supporting information, p. 4278 - 4283 (2021/06/16)
A copper-phosphine system (Cu(OAc)2 and t-Bu3P?HBF4) was used to synthesize α-aminophosphonates and phosphoramides from various aromatic amines and trialkyl phosphites under oxygen atmosphere. With this Cu?P system, α-aminophosphonates containing C?P bonds were generated from N,N-dimethylanilines or N-methylanilines and trialkyl phosphites; phosphoramidates containing N?P bonds were produced from N-benzylanilines and trialkyl phosphites. This strategy provided a convenient and efficient method for the synthesis of phosphorous compounds. The compounds containing phosphoryl group attracted extensive attention due to their biological activities and wide applications.[1,2] The α-aminophosphonates have been applied in medicine and agriculture such as anticancer drugs, antibiotics, antibacterial agents, and enzyme inhibitors.[1] And phosphoramides could be served as antibiotics, prodrugs, flame retardants, and ligands.[2].
