64566-47-8

Upstream product

• 3392-12-9 Boc-Val-ONSu 
• 88489-22-9 Boc-L-Val-L-Orn(Z)-L-Leu-OMe 

Downstream Products

• 88489-24-1 Boc-L-Val-L-Orn(Z)-L-Leu-D-Phe^*-L-Pro-OH 
• 106814-92-0 Boc-Val-Orn(Z)-Leu-N₃ 
• 78834-09-0 Boc-Val-Orn(Z)-Leu-Pro-OH 
• 78834-10-3 H-Val-Orn(Z)-Leu-Pro-OH hydrochloride 
• 89545-54-0 Boc-D-Ala-Val-Orn(Z)-Leu-Pro-OH 
• 78834-11-4 Boc-Asn-Val-Orn(Z)-Leu-Pro-OH 
• 89545-56-2 Boc-D-Ala-Val-Orn(Z)-Leu-Pro-ONSu 
• 78834-13-6 Boc-Asn-Val-Orn(Z)-Leu-Pro-ONSu 
• 104937-61-3 H-Val-Orn(Z)-Leu-BTD-OH*HCl 
• 104937-60-2 Boc-Val-Orn(Z)-Leu-BTD-OSu 
• 102859-50-7 Boc-Val-Orn(Z)-Leu-D-Phe-D-Pro-OSu 
• 102918-56-9 Boc-Val-Orn(Z)-Leu-D-Phe-D-Pro-OH 

Relevant academic research and scientific papers

Facile synthesis of (2R,3R)-phenylalanine-2,3-d2 and NMR study on deuterated gramicidin S1)

(2R,3R)-Phenylalanine-2,3-d2 (D-Phe(*)) was synthesized through catalytic reduction of cyclo-(Z)-2,3-dehydrophenylalanyl-D-alanyl-) under an atmosphere of 2H2 and successive acid hydrolysis in the yield of 80% in high chiral induction. The D-Phe* thus obtained was used for synthesis of [D-Phe *4,4'] gramidicin S (GS*) gramidicin S (GS*). The 1H NMR spectrum of GS* in DMSO-d6 showed a sharp singlet at 2.98 ppm for the (3S)-proton of D-Phe* residue. It has been proposed that among rotamers of D-Phe aromatic side chain in GS the one with κ1 = 180° is predominant. The present observation provides sound evidence for assignments of D-Phe β-protons based on the proposal. (2R,3R)-phenylalanine-2,3-d//2 (d-Phe*) was synthesized through catalytic reduction of cyclo(-(Z)-2,3-dehydrophenylalanyl-D-alanyl-) under an atmosphere of **2H//2 and successive acid hydrolysis in the yield of 80% in high chiral induction. The D-Phe* thus obtained was used for synthesis of left bracket D-Phe***4**,**4** prime right bracket gramicidin S (GS*). The **1H NMR spectrum of GS* in DMSO-d//6 showed a sharp singlet at 2. 98 ppm for the (3S)-proton of D-Phe* residue. It has been proposed that among rotamers of D-Phe aromatic side chain in GS the one with // kappa //1 equals 180 degree is predominant. The present observation provides sound evidence for assignments of D-Phe beta -protons based on the proposal.

FACILE SYNTHESIS OF (2R,3R)-PHENYLALANINE -2,3-d2 AND ITS APPLICATION TO CONFORMATIONAL ANALYSIS OF GRAMICIDIN S

(2R,3R)-Phenylalanine-2,3-d2 was synthesized in a good yield through catalytic reduction of cyclo(-2,3-dehydrophenylalanyl-D-alanyl-) under an atmosphere of 2H2 and successive acid hydrolysis, and the amino acid was used t