64575-42-4Relevant academic research and scientific papers
Facile One-Pot Parallel Synthesis of 3-Amino-1,2,4-triazoles
Bogolyubsky, Andrey V.,Savych, Olena,Zhemera, Anton V.,Pipko, Sergey E.,Grishchenko, Alexander V.,Konovets, Anzhelika I.,Doroshchuk, Roman O.,Khomenko, Dmytro N.,Brovarets, Volodymyr S.,Moroz, Yurii S.,Vybornyi, Mykhailo
, p. 461 - 466 (2018)
A 1,2,4-triazole motif is present in numerous commercialized and investigational bioactive molecules. Despite its importance for medicinal chemistry, there is a lack of convenient combinatorial approaches toward this molecular core. Herein, we present a synthetic strategy suitable for the quick preparation of a library of structurally diverse 1,2,4-triazoles in a one-pot setting. The key steps include the formation of thioureas followed by S-alkylation using 1,3-propane sultone and consecutive ring closure leading to the desired 1,2,4-triazoles. Parallel synthesis yields thousands of 1,2,4-triazoles in a cost- and time-efficient manner from commercially available chemicals.
Nitroimidazoles: Part VII - 1-(1-Alkyl-5-nitroimidazol-2-yl)-aza(diaza,oxaza)cycloalkanes
Nagarajan, K.,Arya, V. P.,George, T.,Bhat, G.A.,Kulkarni, Y. S.,et al.
, p. 949 - 952 (2007/10/02)
Reaction of 1-methyl-2-methylsulphonyl-5-nitroimidazole (2) with pyrrolidine, piperidine and morpholine affords the amines (3a-c)(=9a-c) respectively in low yields, the reaction failing with other bases tried.Analogues (9d-t) have been obtained more readi
