64579-67-5 Usage
Uses
Used in Pharmaceutical Industry:
1-(cyclobutylcarbonyl)piperazine is used as a building block for the synthesis of various pharmaceuticals and biologically active compounds due to its versatile chemical properties and ability to interact selectively with biological targets.
Used in Drug Discovery and Development:
CBP is used as a valuable tool in drug discovery and development, as its unique molecular structure allows for the design of new therapeutic agents with improved efficacy and selectivity.
Used in Anticancer Applications:
1-(cyclobutylcarbonyl)piperazine is used as an anticancer agent, exhibiting a range of biological activities that can potentially lead to the development of new cancer treatments.
Used in Antipsychotic and Antihistaminic Applications:
CBP is used in the development of antipsychotic and antihistaminic drugs, leveraging its biological activities to create new therapeutic agents for the treatment of various mental health and allergic conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 64579-67-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,4,5,7 and 9 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 64579-67:
(7*6)+(6*4)+(5*5)+(4*7)+(3*9)+(2*6)+(1*7)=165
165 % 10 = 5
So 64579-67-5 is a valid CAS Registry Number.
InChI:InChI=1/C9H16N2O/c12-9(8-2-1-3-8)11-6-4-10-5-7-11/h8,10H,1-7H2
64579-67-5Relevant academic research and scientific papers
Discovery of Novel Apigenin-Piperazine Hybrids as Potent and Selective Poly (ADP-Ribose) Polymerase-1 (PARP-1) Inhibitors for the Treatment of Cancer
Long, Huan,Hu, Xiaolong,Wang, Baolin,Wang, Quan,Wang, Rong,Liu, Shumeng,Xiong, Fei,Jiang, Zhenzhou,Zhang, Xiao-Qi,Ye, Wen-Cai,Wang, Hao
, p. 12089 - 12108 (2021/09/06)
Poly (ADP-ribose) polymerase-1 (PARP-1) is a potential target for the discovery of chemosensitizers and anticancer drugs. Amentoflavone (AMF) is reported to be a selective PARP-1 inhibitor. Here, structural modifications and trimming of AMF have led to a series of AMF derivatives (9a-h) and apigenin-piperazine/piperidine hybrids (14a-p, 15a-p, 17a-h, and 19a-f), respectively. Among these compounds, 15l exhibited a potent PARP-1 inhibitory effect (IC50 = 14.7 nM) and possessed high selectivity to PARP-1 over PARP-2 (61.2-fold). Molecular dynamics simulation and the cellular thermal shift assay revealed that 15l directly bound to the PARP-1 structure. In in vitro and in vivo studies, 15l showed a potent chemotherapy sensitizing effect against A549 cells and a selective cytotoxic effect toward SK-OV-3 cells through PARP-1 inhibition. 15l·2HCl also displayed good ADME characteristics, pharmacokinetic parameters, and a desirable safety margin. These findings demonstrated that 15l·2HCl may serve as a lead compound for chemosensitizers and the (BRCA-1)-deficient cancer therapy.
