64579-88-0Relevant academic research and scientific papers
COMPOUNDS, SALTS THEREOF AND METHODS FOR TREATMENT OF DISEASES
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Paragraph 00708; 00709; 00710, (2019/03/12)
The present disclosure relates to compounds according to Formulae disclosed herein, useful for treating diseases.
Study of surfactant alcohols with various chemical moieties at the hydrophilic-hydrophobic interface
Zaffalon, Pierre-Leonard,D'Anna, Vincenza,Hagemann, Hans,Zumbuehl, Andreas
, p. 7237 - 7244 (2013/07/05)
The melting behavior, the solubility, and the influence of hydrogen bonds were analyzed for a series of single- and double-tailed surfactant alcohols. Various effects such as the presence of free amides or the intermolecular spacing were found to be important factors for increasing or decreasing the melting temperature of a surfactant. Furthermore, we present a model for the packing of diamido-lipids and study the temperature-dependence of the IR signals. The Royal Society of Chemistry 2013.
Probing molecular shape. 1. Conformational studies of 5- hydroxyhexahydropyrimidine and related compounds
Locke, Julie M.,Crumbie, Robyn L.,Griffith, Renate,Bailey, Trevor D.,Boyd, Susan,Roberts, John D.
, p. 4156 - 4162 (2008/02/05)
(Chemical Equation Presented) Understanding the factors that determine molecular shape enables scientists to begin to understand and tailor molecular properties and reactivity. Many biomolecules and bioactive compounds contain aliphatic heterocyclic rings whose conformations play a major role in their biological activity. The interplay of a number of factors, both steric and electronic, is examined for 5-hydroxyhexahydropyrimidine (1) and related compounds with use of spectroscopy and molecular modeling.
Synthesis and Characterization of 5-Substituted 1,3-Diazacyclohexane Derivatives
Axenrod, Theodore,Sun, Jianguang,Das, Kajal K.,Dave, Paritosh R.,Forohar, Farhad,Kaselj, Mira,Trivedi, Nirupam J.,Gilardi, Richard D.,Flippen-Anderson, Judith L.
, p. 1200 - 1206 (2007/10/03)
Three synthetic routes to 5-substituted 1,3-diazacyclohexane derivatives 1 are reported. The first method involves treatment of 1,3-diaminopropan-2-ol 2 with paraformaldehyde to yield 5-hydroxy-1,3-diazacyclohexane 3. A second method is based on the condensation of 2-bromo-2-nitro-1,3-propanediol with tert-butylamine and formaldehyde to yield 1,3-di-tert-butyl-5-bromo-5-nitro-1,3-diazacyclohexane 22. The third method relies on the cycloalkylation of methylenebisacetamide with 3-chloro-2-chloromethyl-2-propene to provide 5-exomethylene-1,3-diacetyl-1,3-diazacyclohexane 28. Functional group manipulations of 3, 22, and 28 provide a number of novel 1,3-diazacyclohexanes functionalized at the 5-position.
