6458-60-2

Basic information

• Product Name: 2-BenzoxazolaMine, N-2-pyridinyl-
• Synonyms: 2-BenzoxazolaMine, N-2-pyridinyl-;N-2-Pyridinyl-2-benzoxazolamine;N-(Pyridin-2-yl)benzo[d]oxazol-2-amine
• CAS NO: 6458-60-2
• Molecular Formula: C12H9N3O
• Molecular Weight: 211.21936
• Mol File: 6458-60-2.mol

Chemical Properties

• Melting Point: 223.5-224.0℃
• Appearance: /
• Density: 1.329
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-BenzoxazolaMine, N-2-pyridinyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BenzoxazolaMine, N-2-pyridinyl-(6458-60-2)
• EPA Substance Registry System: 2-BenzoxazolaMine, N-2-pyridinyl-(6458-60-2)

Safety Data

• Hazardous Substances Data: 6458-60-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Benzoxazolamine, N-2-pyridinylis used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new therapeutic agents. Its antifungal and antibacterial activities make it a promising candidate for the creation of treatments targeting a range of infections.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Benzoxazolamine, N-2-pyridinylis utilized as a building block for the preparation of compounds that possess pesticidal properties, thereby playing a role in crop protection and enhancement of agricultural yields.
Used in Materials Science:
2-Benzoxazolamine, N-2-pyridinylis employed as a component in the development of new materials, leveraging its chemical structure to impart specific properties to these materials, such as improved stability or reactivity.
Used in Organic Synthesis:
As a versatile intermediate, 2-Benzoxazolamine, N-2-pyridinylis used in organic synthesis for the preparation of a wide array of valuable chemicals, contributing to the advancement of chemical research and the creation of novel compounds with diverse applications.

Upstream product

• 109-04-6 2-bromo-pyridine 
• 4570-41-6 1,3-benzoxazol-2-amine 
• 504-29-0 2-aminopyridine 
• 4694-88-6 benzooxazole-2-sulfonic acid; potassium salt 

Relevant articles and documents

COMPOSITIONS COMPRISING A PI3K INHIBITOR AND AN HDAC INHIBITOR

The invention relates to a pharmaceutical composition comprising at least one PI3K inhibitor of Formula I or a pharmaceutically acceptable salt thereof and at least one HDAC inhibitor such as a compound of Formula II or a pharmaceutically acceptable salt thereof; or at least one PI3K inhibitor such as a compound of Formula I or a pharmaceutically acceptable salt thereof and at least one HDAC inhibitor of Formula II or a pharmaceutically acceptable salt thereof.

COMBINATIONS COMPRISING HISTONE DEACETYLASE INHIBITORS

The invention relates to a combination of a compound of formula (I) or a pharmaceutically acceptable salt thereof, and at least one second agent selected from the group consisting of proteasome inhibitors, tumour immunotherapeutics or immunomodulatory agents, signal transduction pathway inhibitors, agents inhibiting the BCL2 family of proteins, agents inhibiting Mcl-1, poly (ADP-ribose) polymerase (PARP) Inhibitors, aromatase inhibitors, conventional cytotoxic agents or a miscellaneous agent selected from abiraterone, ARN-509 and MYC inhibitors.

NOVEL HISTONE DEACETYLASE INHIBITORS AND THEIR USE IN THERAPY

A compound of the formula:(I) or a pharmaceutically acceptable salt thereof, wherein: L is a 5-membered nitrogen-containing heteroaryl which is optionally fused to a benzene; Y is a 5, 6 or 7-membered nitrogen-containing heteroaryl, which is optionally fused to a benzene; and W is a zinc-binding group. The compounds are HDAC inhibitors and therefore have potential utility in therapy.

NOVEL HISTONE DEACETYLASE INHIBITORS

The present invention is a compound of the formula or a pharmaceutically acceptable salt thereof. The compounds are useful as HDAC inhibitors.