64597-37-1Relevant academic research and scientific papers
Acid-promoted palladium(II)-catalyzed ortho-halogenation of primary benzamides: En route to halo-arenes
Jaiswal, Yogesh,Kumar, Amit
, (2019/08/26)
Br?nsted acid-promoted palladium(II)-catalyzed regioselective installation of halogens (Br, Cl, and I) to the aromatic ring of benzamide derivatives has been achieved using primary amides. A wide variety of benzamides were compatible under established conditions to afford the halogenated products without installing any external auxiliary. Mild reaction conditions, use of primary amide as a directing group, external additive-free conditions, and gram-scale reaction are some appealing features of this protocol. Detailed experimental results revealed that Br?nsted acid plays a critical role in this transformation.
Discovery of 5-Chloro-1-(5-chloro-2-(methylsulfonyl)benzyl)-2-imino-1,2-dihydropyridine-3-carboxamide (TAK-259) as a Novel, Selective, and Orally Active α1D Adrenoceptor Antagonist with Antiurinary Frequency Effects: Reducing Human Ether-a-go-g
Sakauchi, Nobuki,Kohara, Yasuhisa,Sato, Ayumu,Suzaki, Tomohiko,Imai, Yumi,Okabe, Yuichi,Imai, Shigemitsu,Saikawa, Reiko,Nagabukuro, Hiroshi,Kuno, Haruhiko,Fujita, Hisashi,Kamo, Izumi,Yoshida, Masato
, p. 2989 - 3002 (2016/05/19)
A novel structural class of iminopyridine derivative 1 was identified as a potent and selective human α1D adrenoceptor (α1D adrenergic receptor; α1D-AR) antagonist against α1A- and α1B-AR through scre
