64600-20-0Relevant academic research and scientific papers
Copper-Catalyzed Fluoroolefination of Silyl Enol Ethers and Ketones toward the Synthesis of β-Fluoroenones
Li, Yanlin,Liu, Jing,Zhao, Shuang,Du, Xuzhao,Guo, Minjie,Zhao, Wentao,Tang, Xiangyang,Wang, Guangwei
, p. 917 - 920 (2018)
A general and facile synthetic method for β-fluoroenones from silyl enol ethers or ketones, with a copper-amine catalyst system, has been developed. The reaction proceeded by a tandem process of difluoroalkylation-hydrolysis-dehydrofluorination. This method is characterized by high yields, excellent Z/E ratios, a low-cost catalyst, and a broad substrate scope. The synthetic potential of β-fluoroenones has been demonstrated by the construction of various complicated organofluorine molecules.
