646026-96-2Relevant academic research and scientific papers
Sequential reductive amination-hydrogenolysis: A one-pot synthesis of challenging chiral primary amines
Nugent, Thomas C.,Negru, Daniela E.,El-Shazly, Mohamed,Hu, Dan,Sadiq, Abdul,Bibi, Ahtaram,Umar, M. Naveed
, p. 2085 - 2092 (2011/10/19)
Difficult-to-access chiral primary amines were formed in good to high yield and ee using a rare example of a one-pot synthesis from prochiral ketones (sequential reductive amination-hydrogenloysis). As a highlight we also demonstrate a one-pot reductive amination-hydrogenolysis-reductive amination (five reactions) of ortho-methoxyacetophenone resulting in the chiral diamine 1-(2-methoxyphenyl)ethyl-(2-pyridylmethyl)-amine (4) (58% overall yield, >99% ee), a new organocatalyst for aqueous enantioselective aldol reactions. Copyright
A Dramatic Effect of Aryloxo Ligands on the Titanium-Catalyzed Hydroamination of Alkynes
Khedkar, Vivek,Tillack, Annegret,Beller, Matthias
, p. 4767 - 4770 (2007/10/03)
(Equation Presented) The aryloxotitanium complex 1 is a highly chemo- and regioselective catalyst for intermolecular hydroamination of terminal alkynes. Branched imines are obtained in good to excellent yield (up to 99%) with various primary aromatic and aliphatic amines.
Aminoborohydrides. 6. Diastereoselective Reduction of the Carbon-Nitrogen Double Bond in Chiral Imines Using Lithium Diethylaminoborohydride and Lithium Diisopropylaminoborohydride.
Fuller, Joseph C.,Belisle, Christopher M.,Goralski, Christian T.,Singaram, Bakthan
, p. 5389 - 5392 (2007/10/02)
Lithium aminoborohydrides (LAB), obtained by the reaction of n-BuLi with amine-boranes, readily reduce imines to the corresponding secondary amines.Lithium diethylaminoborohydride and lithium diisopropylaminoborohydride reduc
