64603-92-5

Basic information

• Product Name: Trans sodiuM crocetinate
• Synonyms: Trans sodiuM crocetinate;IZSRZQNWALWJRR-VFWKRBOSSA-N
• CAS NO: 64603-92-5
• Molecular Formula: C₂₀H₂₂O₄*2Na
• Molecular Weight: 372.36582
• Mol File: 64603-92-5.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Trans sodiuM crocetinate(CAS DataBase Reference)
• NIST Chemistry Reference: Trans sodiuM crocetinate(64603-92-5)
• EPA Substance Registry System: Trans sodiuM crocetinate(64603-92-5)

Safety Data

• Hazardous Substances Data: 64603-92-5(Hazardous Substances Data)

Upstream product

• 121666-37-3 <3-(Methoxycarbonyl)-2-butenyl>triphenylphosphoniumbromid 
• 129144-90-7 2-methyl-4-(triphenyl-λ⁵-phosphoranylidene)but-2-enoic acid methyl ester 
• 130121-15-2 Ethyl (2E,4E)-2-methyl-6-oxohexa-2,4-dienoate 
• 64768-01-0 diethyl 2,7-dimethyl-2(E),4(E),6(E)-octatriene-1,8-dioate 
• 113951-62-5 (2E,4E,6E)-2,6-dimethylocta-2,4,6-triene-1,8-diol 
• 80-59-1 Tiglic acid 
• 6622-76-0 methyl (E)-2-methyl-2-butenoate 
• 136949-10-5 (2E,4E)-Ethyl 6,6-Dimethoxy-2-methylhexa-2,4-dienoate 
• 5056-17-7 (2E,4E,6E)-2,7-dimethyl-2,4,6-octatrienedial 
• 99968-60-2 methyl (E)-4-bromo-2-methylbut-2-enoate 
• 211677-08-6 tetraethyl trans-2-butenyl-1,4-bisphosphonate 
• 5056-17-7 2,7-dimethyl-2,4,6-octanetriene-1,8-dialdehyde 
• 5056-14-4 diethyl crocetinate 
• 5892-54-6 Crocetindimethylester 

Downstream Products

• 27876-94-4 crocetin 

Relevant articles and documents

METHODS OF SYNTHESIZING CAROTENOIDS

Provided herein novel processes for preparing carotenoids, substantially pure carotenoids (such as substantially pure trans crocetin diesters and substantially pure trans sodium crocetinate), pharmaceutical compositions, and related methods of treatment and uses. The provided compositions have uses in treating diseases, disorders and conditions associated with, but not limited to, infection, ARDS, endotoxemia, inflammation, sepsis, ischemia, hypoxia, shock, stroke, lung injury, wound healing, traumatic injury, reperfusion injury, cardiovascular disease, kidney disease, liver disease, inflammatory disease, metabolic disease, pulmonary disorders, blood related disorders and hyperproliferative diseases such as cancer. Methods of making, and using the aqueous solutions and pharmaceutical compositions are also provided.

Characterization of the Saffron Derivative Crocetin as an Inhibitor of Human Lactate Dehydrogenase 5 in the Antiglycolytic Approach against Cancer

Inhibition of lactate dehydrogenase (LDH) represents an innovative approach to tackle cancer because this peculiar glycolytic metabolism is characteristic of most invasive tumor cells. An investigation into the biological properties of saffron extracts led to the discover of their LDH-inhibition properties. In particular, the most important saffron components, crocetin, was found to inhibit LDH (IC50 = 54.9 ± 4.7 μM). This carotenoid was independently produced by chemical synthesis, and its LDH-inhibition properties manifested via its antiproliferative activity against two glycolytic cancer cell lines (A549 and HeLa, IC50 = 114.0 ± 8.0 and 113.0 ± 11.1 μM, respectively). The results described in this article suggest that saffron may be a helpful alimentary component in the prevention of cancer that potentially contributes to the efficacy of approved cancer therapies.

Trans carotenoids, their synthesis, formulation and uses

The invention relates to trans carotenoid compounds and salts thereof as well as compositions thereof, methods for making them, and uses thereof. These compounds are useful in improving diffusivity of oxygen between red blood cells and body tissues in mammals including humans.