646037-75-4Relevant academic research and scientific papers
Direct asymmetric syn-aldol reactions of linear aliphatic ketones with primary amino acid-derived diamines
Demuynck, Anneleen L. W.,Vanderleyden, Jozef,Sels, Bert F.
, p. 2421 - 2426 (2010)
We have designed a novel class of chiral diamine organocatalysts based on natural primary amino acids that efficiently catalyze syn-selective aldol reactions of challenging linear ketones, such as 2-butanone, and aromatic aldehydes. In the presence of trifluoroacetic acid (TFA) as Bronsted acid and 2,4-dinitrophenol (DNP) as co-catalyst, syn-aldol products have been obtained with excellent enantioselectivities of up to> 99% ee.
