64614-48-8

Usage

Uses

Used in Pharmaceutical Industry:
2-chloro-5-(piperidin-1-ylcarbonyl)pyridine is used as a key intermediate for the synthesis of new pharmaceuticals and agrochemicals. Its chloro group facilitates nucleophilic substitution reactions, allowing for the attachment of various functional groups to the molecule. The piperidinylcarbonyl group provides a site for potential interactions with biological targets, enhancing the compound's bioactivity.
Used in Medicinal Chemistry:
2-chloro-5-(piperidin-1-ylcarbonyl)pyridine is employed as a versatile chemical in medicinal chemistry for the development of new drugs and therapeutic agents. Its unique structure and reactivity enable the design and synthesis of compounds with specific biological activities, targeting various diseases and conditions.
Used in Drug Discovery:
2-chloro-5-(piperidin-1-ylcarbonyl)pyridine is also used in drug discovery research, where it serves as a target for further exploration and development. Its potential applications in medicinal chemistry and drug discovery make 2-chloro-5-(piperidin-1-ylcarbonyl)pyridine a promising candidate for the identification of novel therapeutic agents and the advancement of pharmaceutical research.

InChI:InChI=1/C11H13ClN2O/c12-10-5-4-9(8-13-10)11(15)14-6-2-1-3-7-14/h4-5,8H,1-3,6-7H2

Upstream product

• 110-89-4 piperidine 
• 58757-38-3 6-Chloronicotinoyl chloride 
• 73781-91-6 6-Chloronicotinic acid methyl ester 

Downstream Products

• 571914-46-0 C₁₈H₂₁N₃O 
• 571913-90-1 C₁₈H₂₁N₃O₂ 
• 571913-68-3 C₁₇H₁₉N₃O 
• 581054-29-7 C₁₇H₁₈ClN₃O 
• 1204316-89-1 C₁₇H₁₇Cl₂N₃O 

Relevant academic research and scientific papers

Chemo-selective syntheses of: N-t -boc-protected amino ester analogs through Buchwald-Hartwig amination

The synthesis of N-protected amino esters is achieved via a chemo-selective Buchwald Hartwig cross-coupling reaction using PEPPSI-IPr Pd-catalyst. Nearly two dozen functionally and structurally diverse amino ester molecules are created by individually cross-coupling eight aryl halo esters and three different secondary amines. We observed that product formation is more facile in those heterocyclic esters where nitrogen is present ortho to the halo substituent in the heteroaromatic ring. Based on this observation, we propose a possible intermediate step in the cross-coupling cycle, where the nitrogen electron lone pair in the heterocycle may play an important role leading to a higher reaction yield.

Piperidyl amides as novel, potent and orally active mGlu5 receptor antagonists with anxiolytic-like activity

High throughput screening led to the identification of nicotinamide derivative 2 as a structurally novel mGluR5 antagonist. Optimization of the modular scaffold led to the discovery of 16m, a compound with high affinity for mGluR5 and excellent selectivit

NICOTINIC ACID DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS

The present invention relates to novel nicotinic acid derivatives, of formula (I), wherein the substituents are defined in the specification, their preparation, their use as pharmaceuticals and pharmaceutical compositions containing them.