64633-76-7Relevant academic research and scientific papers
Method for preparing 2-alkylthiobenzonitrile
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Paragraph 0015-0018; 0027-0028; 0031-0032, (2022/01/07)
The invention relates to the technical field of fine chemical engineering, and discloses a method for preparing 2-alkylthiobenzonitrile, the method specifically comprises the following steps: taking 2-alkylthiobenzonamide as a raw material and sodium iodide, acetic acid and 1-chloromethyl-4-fluoro-1, 4-diazabicyclo [2.2. 2] octane bis (tetrafluoroborate) [Selectfluor] as additives, reacting in acetonitrile at 120 DEG C for 24 hours, and obtaining the target product 2-alkyl thiobenzonitrile. The method is easy and convenient to operate, reagents and raw materials are easy to obtain, phosphorus oxychloride which is high in toxicity and not easy to store does not need to be used as a dehydrating agent, 2-alkylthiobenzonitrile is efficiently synthesized in one step, and potential application value is achieved.
QUINAZOLINEDIONE DERIVATIVE
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Paragraph 0204; 0372; 0373, (2015/03/16)
The present invention relates to quinazolinedione derivatives represented by formula (I) or pharmaceutically acceptable salts thereof.
Method for producing 1,2-benzisothiazol-3-ones
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, (2008/06/13)
A method for producing a 1,2-benzisothiazol-3-one, having the steps of carrying out a reaction of a 2-(alkylthio)benzaldehyde with a hydroxylamine to give a 2-(alkylthio)benzaldehyde oxime and carrying out a reaction of the 2-(alkylthio)benzaldehyde oxime with a halogenating agent; and a method for producing a 1,2-benzisothiazol-3-one, having the steps of carrying out a reaction of a 2-halobenzonitrile with an alkanethiol in a heterogeneous solvent system in the presence of a base to give a 2-(alkylthio)benzonitrile and carrying out a reaction of the 2-(alkylthio)benzonitrile with an halogenating agent in the presence of water.
ETUDE DES REACTIONS DE SRN1-PARTIE 10 ACTION DE SULFANIONS SUR LES HALOGENURES D'ARYLE FONCTIONNALISES. SYNTHESE DIRECTE DE BENZOTHIOPHENES ET THIENOPYRIDINES
Beugelmans, Rene,Bois-Choussy, Michele,Boudet, Bernard
, p. 4153 - 4162 (2007/10/02)
Functionalized aromatic halides Ar1XY (Ar1=C6H4, Y=OCH3,CONH2,CN,COCH3,CHO,COC6H5) undergo SRN1 reactions with sulphur anions -SR, either simple (R=C2H5,CH2C6H5) or functionalized (R=(CH2)2OH,(CH2)2CO2Et,CH2CO2Et).Products Ar1YS- formed from the fragmentation of the radical anion Ar1YSR- are related to the redox potential of the aryl moiety Ar1Y and with the energy of the bond S-R.In the heterocyclic series (Ar2=pyridine, Ar3=quinoline) a similar relationship appears but a competitive SN(AR) reaction occurs for pyridine substrates bearing an electron withdrawing group.A direct synthesis of benzothiophen via SRN1 reaction and an improved synthesis of thienopyridines based on the SN(Ar) reaction are reported.
