64638-16-0

Basic information

• Product Name: {1-[3-(2-chloro-phenothiazin-10-yl)-propyl]-piperidin-4-yl}-(3,4-dichloro-phenyl)-methanone
• CAS NO: 64638-16-0
• Molecular Weight: 531.933
• Mol File: 64638-16-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: {1-[3-(2-chloro-phenothiazin-10-yl)-propyl]-piperidin-4-yl}-(3,4-dichloro-phenyl)-methanone(CAS DataBase Reference)
• NIST Chemistry Reference: {1-[3-(2-chloro-phenothiazin-10-yl)-propyl]-piperidin-4-yl}-(3,4-dichloro-phenyl)-methanone(64638-16-0)
• EPA Substance Registry System: {1-[3-(2-chloro-phenothiazin-10-yl)-propyl]-piperidin-4-yl}-(3,4-dichloro-phenyl)-methanone(64638-16-0)

Safety Data

• Hazardous Substances Data: 64638-16-0(Hazardous Substances Data)

Upstream product

• 2765-59-5 2-chloro-10-(3-chloropropyl)-10H-phenothiazine 
• 64638-17-1 (3,4-dichloro-phenyl)-piperidin-4-yl-methanone; hydrochloride 

Relevant articles and documents

(1-(3-(Phenothiazin-10-yl)propyl)-4-piperidinyl)phenylmethanones, a novel class of long-acting neuroleptic agents.

In previous studies the phenyl-4-piperidinylmethanone moiety was shown to be a neuroleptic pharmacophore. A short series of [1-[3-(phenothiazin-10-yl)propyl]-4-piperidinyl]phenylmethanones was prepared and tested for neuroleptic activity using the blockade of d-amphetamine lethality in aggregated mice and suppression of conditioned avoidance behavior as the end points. Most compounds were shown to be potent neuroleptic agents and two were found to possess a long duration of action.