64643-72-7

Usage

Uses

Used in Pharmaceutical Industry:
(5alpha)-17-(cyclobutylcarbonyl)-4,5-epoxy-14-hydroxy-3-methoxymorphinan-6-one is used as a potential analgesic for the treatment of pain due to its opioid-like properties stemming from its morphinan structure.
Used in Addiction Treatment:
(5alpha)-17-(cyclobutylcarbonyl)-4,5-epoxy-14-hydroxy-3-methoxymorphinan-6-one is used as a potential therapeutic agent for the treatment of opioid addiction, leveraging its morphinan structure to help manage withdrawal symptoms and reduce cravings.

Upstream product

• 25774-35-0 cyclobutanecarboxylic anhydride 
• 76-42-6 Oxycodone 
• 64643-74-9 C₂₃H₂₇NO₅ 
• 64643-73-8 C₂₂H₂₅NO₅*ClH 
• 90150-73-5 14-cyclobutanecarbonyl-4,5α-epoxy-3-methoxy-morphinan-6-one; hydrochloride 

Downstream Products

• 64643-71-6 17-cyclobutylmethyl-4,5α-epoxy-14-hydroxy-3-methoxy-morphinan-6-one 
• 20594-83-6 nalbuphine 

Relevant academic research and scientific papers

A New Reagent for the Selective, High-Yield N-Dealkylation of Tertiary Amines: Improved Syntheses of Naltrexone and Nalbuphine

Secondary amine hydrochlorides are obtained in high yield by reaction of tertiary amines with α-chloroethyl chloroformate followed by warming the intermediate carbamate in methanol.

N-alkyl-14-hydroxymorphinans and derivatives

There is provided a novel and high yield procedure for transforming acid salts of 14-alkanoyloxymorphinans and derivatives thereof into the corresponding N-alkyl-14-hydroxymorphinans wherein the alkyl moiety on the nitrogen contains the same number of carbon atoms as that previously in the 14-alkanoyl moiety. In the process of the present invention, the acid is neutralized to the free base, the alkanoyl moiety at the 14-oxy then spontaneously shifts to the nitrogen and is subsequently reduced to the corresponding alkyl moiety. O-dealkylation at C-3, where an alkoxy group is originally present, is carried out in the usual manner. There is also provided a readily produced and readily disassociated adduct of the corresponding 14-hydroxy-N-alkanoyl morphinan-6-alkylene ketal with benzene, tetrahydrofuran, and the like.