646507-90-6Relevant academic research and scientific papers
N-(4-biphenylmethyl)imidazoles as potential therapeutics for the treatment of prostate cancer: Metabolic robustness due to fluorine substitution?
Leroux, Frederic,Hutschenreuter, Tilman U.,Charriere, Celine,Scopelliti, Rosario,Hartmann, Rolf W.
, p. 2671 - 2686 (2003)
3,3′,5,5′- And 2,2′,6,6′-tetrafluoro-substituted 1-[(1,1′-biphenyl]-4-yl)methyl]-1H-imidazoles were synthesized as inhibitors of 17α-hydroxylase-C17,20-lyase (P450 17, CYP 17). P450 17 is the key enzyme of androgen biosynthesis. Its inhibition is a novel
